Results 21 to 30 of about 10,447 (217)

Concerted Action of Targeted Nucleic Acid Therapeutics as Flexible, Precision and Personalized Cancer Treatment

Advanced Science, EarlyView.
Combinations of small activating RNAs and small interfering RNAs were developed as personalized precision therapies that simultaneously activate tumor suppressors and silence oncogenes according to the molecular signatures of patient tumors. This combination strategy demonstrated superior anticancer efficacy, highlighting the promise of precision ...
Jing Wu, Jiaxuan Chen, Abdechakour Elkihel, Wenjun Lan, Nicolas Fraunhoffer, Dandan Zhu, Baoping Lian, Christina Galanakou, Zhancun Bian, Xi Liu, Odile Gayet, Loic Moubri, Julie Aglietti Roques, Vikash Reebye, Nagy Habib, Xiaoxuan Liu, Nelson Dusetti, Juan Lucio Iovanna, Ling Peng   +18 more
wiley   +1 more source

CORRELATION BETWEEN PATHOLOGY AND EXCESS OF MAXIMUM CONCENTRATION LIMIT OF POLLUTANTS IN THE ENVIRONMENT OF THE REPUBLIC OF DAGESTAN

Юг России: экология, развитие, 2014
. Statistical data from "Indicators of health status of the Republic of Dagestan" for 1999 - 2010 years are presented in the work. The aim of this work was to identify a cause-effect correlation between non-communicable diseases (ischemic heart disease ...
G. M. Abdurakhmanov, E. S. Erzhapova, M. G. Daudova   +2 more
doaj   +1 more source

A case of brachial artery infected aneurysm secondary to infective endocarditis from intramuscular steroid use

Indian Journal of Vascular and Endovascular Surgery, 2021
Infected aneurysms are a subset of aneurysms associated with infection. Approximately 10% of infected aneurysms involve the upper extremity. Infected aneurysms present a management challenge as patients are often unwell with concomitant infective ...
Thomas Lovelock, Anastasia Dean, Ayushica Saran, Thodur Vasudevan   +3 more
doaj   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Case report: Bordetella holmesii: A rare pathogen causing infective endocarditis associated glomerulonephritis

Frontiers in Pediatrics, 2023
Infective endocarditis (IE) can cause multiorgan dysfunction and chronic kidney disease, in addition to cardiac sequelae. The presentation may be vague and can manifest as acute glomerulonephritis.
Tara Gavcovich, Tara Gavcovich, Malek Al Barbandi, Malek Al Barbandi, Pamela Millan, Pamela Millan, Elizabeth Isner, Marissa J. Defreitas, Marissa J. Defreitas, Wendy Glaberson, Wendy Glaberson, Chryso P. Katsoufis, Chryso P. Katsoufis, Jayanthi Chandar, Jayanthi Chandar, Vaka Sigurjonsdottir, Vaka Sigurjonsdottir, Ivan A. Gonzalez, Ivan A. Gonzalez, Sethuraman Swaminathan, Sethuraman Swaminathan, Yiqin Zuo, Carolyn L. Abitbol, Carolyn L. Abitbol, Wacharee Seeherunvong, Wacharee Seeherunvong   +25 more
doaj   +1 more source

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Obstruction of left ventricular outflow tract by a calcified mass at mitral valve [PDF]

Medicinski Glasnik, 2010
A case of an unusual left ventricular outflow tract obstruction by mitral valve pathology in a 35-year old female with diabetes and end-stage renal disease is presented in the study.
Miro Bakula, Zeljka Gavranovic, Maja Bakula, Roman Urek, Nikola Jankovic, Goran Milicevic   +5 more
doaj  

STUDY OF THE STATE OF ENT-ORGANS IN CHILDREN WITH ANOMALIES AND DEFORMATIONS OF DENTOALVEOLAR APPARATUS AND SPEECH DISORDERS

Український стоматологічний альманах, 2018
The relevance of research. When examining patients with dentoalveolar anomalies, children with speech disorders can often be observed. For orthodontists, it is important to diagnose the etiologic component of these disorders, namely, whether they are ...
P.S. Flis, N.V. Raschenko, A.O. Melnyk, V.V. Filonenko, O.I. Kotov   +4 more
doaj   +1 more source

Multifunctional Zinc Glycyrrhizinate‐Integrated Gel for Enhanced Probiotic Delivery and Alleviation of Acute and Spontaneous Colitis

Advanced Science, EarlyView.
Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Mengyun Peng, Xiaochun Chen, Wei Li, Shu Tang, Jun Zhou, Xia Wu, Dan Yuan, Zhongyan Shan, Junfeng Shi   +8 more
wiley   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source