Results 161 to 170 of about 482,957 (287)

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

Evaluation of <i>XRCC4</i> and <i>VEGF</i> Gene Variants in Relation to Breast Cancer Risk in a Jordanian Cohort. [PDF]

Cancer Manag Res
Al-Eitan L, Almomani F, Alorjani M, Alasmar M, Alsatari R, Bahdar T, Alghamdi M.   +6 more
europepmc   +1 more source

YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis.

Developmental Cell, 2017
Xiaohong Wang, Aida Freire Valls, Géza Schermann, Ying Shen, I. Moya, Laura Castro, Severino Urban, G. Solecki, F. Winkler, L. Riedemann, R. Jain, M. Mazzone, T. Schmidt, Tamás Fischer, G. Halder, Carmen Ruiz de Almodóvar   +15 more
semanticscholar   +1 more source

CA9‐Targeted PET Imaging for Noninvasive Discrimination of Clear Cell Renal Cell Carcinoma and Associated Tumor Biological Features

Advanced Science, EarlyView.
CA9‐targeted PET imaging could be a noninvasive approach to characterize clear cell renal cell carcinoma and associated tumor biology. PET uptake correlates with tumor CA9 expression and is linked to angiogenic activity, immune remodeling, and metabolic reprogramming.
Kailei Chen, Sixuan Cheng, Jian Shi, Ruijie Liu, Yilong Wu, Xin Zheng, Xinlun Song, Yunxuan Zhang, Lei Liu, Zhihao Wei, Qi Wang, Xinwei Li, Zirui Dong, Yuenan Liu, Hongmei Yang, Xiaoli Lan, Chunxia Qin, Dawei Jiang, Keshan Wang, Xiaoping Zhang   +19 more
wiley   +1 more source

A simple, rapid, resin-free platform for purification of vascular endothelial growth factor using a calcium-responsive fusion protein. [PDF]

Bioresour Bioprocess
Lee J, Park H, Im K, Byun S, Kim S.
europepmc   +1 more source

VEGF-Trap: A VEGF blocker with potent antitumor effects

Proceedings of the National Academy of Sciences of the United States of America, 2002
J. Holash, S. Davis, N. Papadopoulos, S. Croll, L. Ho, M. Russell, P. Boland, Raymond Leidich, D. Hylton, E. Burova, E. Ioffe, Tammy Huang, C. Radziejewski, Kevin Bailey, J. Fandl, T. Daly, S. Wiegand, G. Yancopoulos, J. Rudge   +18 more
semanticscholar   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Rhizoma Dioscoreae Nipponicae attenuates airway remodeling and angiogenesis-related changes in asthma with altered mTOR/4EBP1/HIF-1α/VEGF pathway markers. [PDF]

World Allergy Organ J
Zhou X, Wang Z, Zheng S.
europepmc   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Intraoperative Anti-VEGF vs. Photocoagulation during Vitrectomy for Branch Retinal Vein Occlusion with Vitreous Hemorrhage: A Randomized Clinical Trial. [PDF]

Ophthalmol Sci
Lin W, Deng C, Lin Z, Pan Q, Tang Y, Chen H, Lin X, Wei Y.   +7 more
europepmc   +1 more source