Nuclear protein kinase C isoforms and apoptosis
European Journal of Histochemistry, 2009 The process of apoptosis is regulated at multiple levels through phosphorylation by several different protein kinases. The protein kinase C (PKC) family of isozymes have been shown to exert both inhibitory and stimulatory influences on apoptosis.
AM Martelli, G Mazzotti, S Capitani
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Abundance and localization of human UBE3A protein isoforms [PDF]
Human Molecular Genetics, 2020 Abstract Loss of UBE3A expression, a gene regulated by genomic imprinting, causes Angelman Syndrome (AS), a rare neurodevelopmental disorder. The UBE3A gene encodes an E3 ubiquitin ligase with three known protein isoforms in humans.
Carissa L Sirois +2 more
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Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations [PDF]
Scientific Reports, 2023 Splice modulating antisense oligomers (AOs) are increasingly used to modulate RNA processing. While most are investigated for their use as therapeutics, AOs can also be used for basic research.
Jessica M. Cale +6 more
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HETEROGENEITY OF PRESYNAPTIC PROTEINS: DO NOT FORGET ISOFORMS [PDF]
Frontiers in Cellular Neuroscience, 2013 Analysis of presynaptic protein expression in glutamatergic and GABAergic central synapses performed in several laboratories and with different techniques is unveiling a complex scenario, largely because each presynaptic protein exists in several ...
Luca eBragina +10 more
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DeepLPI: a multimodal deep learning method for predicting the interactions between lncRNAs and protein isoforms [PDF]
BMC Bioinformatics, 2021 Background Long non-coding RNAs (lncRNAs) regulate diverse biological processes via interactions with proteins. Since the experimental methods to identify these interactions are expensive and time-consuming, many computational methods have been proposed.
Dipan Shaw +3 more
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IsoSVM – Distinguishing isoforms and paralogs on the protein level [PDF]
BMC Bioinformatics, 2006 Background Recent progress in cDNA and EST sequencing is yielding a deluge of sequence data. Like database search results and proteome databases, this data gives rise to inferred protein sequences without ready access to the underlying genomic data ...
Sczyrba Alexander +4 more
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Brain clusterin protein isoforms and mitochondrial localization [PDF]
eLife, 2019 Clusterin (CLU), or apolipoprotein J (ApoJ), is the third most predominant genetic risk factor associated with late-onset Alzheimer’s disease (LOAD). In this study, we use multiple rodent and human brain tissue and neural cell models to demonstrate that ...
Sarah K Herring +4 more
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Functional Study of Carboxylesterase 1 Protein Isoforms. [PDF]
Proteomics, 2019 Abstract Carboxylesterase 1 (CES1) is a primary human hepatic hydrolase involved in hydrolytic biotransformation of numerous medications. Considerable interindividual variability in CES1 expression and activity has been consistently reported. Four isoforms of the CES1 protein are produced by alternative splicing (AS).
Wang X, Shi J, Zhu HJ.
europepmc +4 more sources
ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures [PDF]
Nucleic Acids ResearchRongbin Li +2 more
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From protein-protein to isoform-isoform interactions: the toolkit to map alternative splicing to interactome [PDF]
From protein-protein to isoform-isoform interactions: the toolkit to map alternative splicing to interactome, 2023 Alternative splicing (AS) can impact protein structure and lead to protein-protein interaction (PPI) rewiring. Available PPI networks neglect alternative splicing isoforms: as interactions might happen only between a subset of isoforms, the PPI network contains both false-positive and false-negative interactions.
Olga Tsoy +6 more
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