Results 11 to 20 of about 407,396 (256)
Functional Study of Carboxylesterase 1 Protein Isoforms [PDF]
Proteomics, 2019 Abstract Carboxylesterase 1 (CES1) is a primary human hepatic hydrolase involved in hydrolytic biotransformation of numerous medications. Considerable interindividual variability in CES1 expression and activity has been consistently reported. Four isoforms of the CES1 protein are produced by alternative splicing (AS).
Xinwen Wang, Hao-Jie Zhu, Jian Shi
exaly +5 more sources
Nuclear protein kinase C isoforms and apoptosis
European Journal of Histochemistry, 2009 The process of apoptosis is regulated at multiple levels through phosphorylation by several different protein kinases. The protein kinase C (PKC) family of isozymes have been shown to exert both inhibitory and stimulatory influences on apoptosis.
AM Martelli, G Mazzotti, S Capitani
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HETEROGENEITY OF PRESYNAPTIC PROTEINS: DO NOT FORGET ISOFORMS [PDF]
Frontiers in Cellular Neuroscience, 2013 Analysis of presynaptic protein expression in glutamatergic and GABAergic central synapses performed in several laboratories and with different techniques is unveiling a complex scenario, largely because each presynaptic protein exists in several ...
Luca eBragina +10 more
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IsoSVM – Distinguishing isoforms and paralogs on the protein level [PDF]
BMC Bioinformatics, 2006 Background Recent progress in cDNA and EST sequencing is yielding a deluge of sequence data. Like database search results and proteome databases, this data gives rise to inferred protein sequences without ready access to the underlying genomic data ...
Sczyrba Alexander +4 more
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From protein-protein to isoform-isoform interactions: the toolkit to map alternative splicing to interactome [PDF]
From protein-protein to isoform-isoform interactions: the toolkit to map alternative splicing to interactome, 2023 Alternative splicing (AS) can impact protein structure and lead to protein-protein interaction (PPI) rewiring. Available PPI networks neglect alternative splicing isoforms: as interactions might happen only between a subset of isoforms, the PPI network contains both false-positive and false-negative interactions.
Olga Tsoy +6 more
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The Isoforms of the p53 Protein [PDF]
Cold Spring Harbor Perspectives in Biology, 2009 p53 is a transcription factor with a key role in the maintenance of genetic stability and therefore preventing cancer formation. It belongs to a family of genes composed of p53, p63, and p73. The p63 and p73 genes have a dual gene structure with an internal promoter in intron-3 and together with alternative splicing, can express 6 and 29 mRNA variants,
Khoury, Marie P. +1 more
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Isoforms of the class II transactivator protein [PDF]
International Immunology, 2002 The class II transactivator (CIITA) controls both the constitutive and IFN-gamma inducible expression of HLA-D genes. In addition, through the squelching of another transactivator CREB-binding protein, CIITA was more recently shown to have a wider cellular function, including cell cycle control or cellular response to IFN-gamma and IL-4.
Barbieri G +10 more
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Efficient Detection of the Alternative Spliced Human Proteome Using Translatome Sequencing
Frontiers in Molecular Biosciences, 2022 Alternative splicing (AS) isoforms create numerous proteoforms, expanding the complexity of the genome. Highly similar sequences, incomplete reference databases and the insufficient sequence coverage of mass spectrometry limit the identification of AS ...
Chun Wu +11 more
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Characteristics of Human OAS1 Isoform Proteins [PDF]
Viruses, 2020 The human OAS1 (hOAS1) gene produces multiple possible isoforms due to alternative splicing events and sequence variation among individuals, some of which affect splicing. The unique C-terminal sequences of the hOAS1 isoforms could differentially affect synthetase activity, protein stability, protein partner interactions and/or cellular localization ...
Han Di, Husni Elbahesh, Margo A. Brinton
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Frontiers in Microbiology, 2023 The largest family of transmembrane receptors are G-protein-coupled receptors (GPCRs). These receptors respond to perceived environmental signals and infect their host plants. Family A of the GPCR includes opsin.
Marzieh Mohri +3 more
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