Results 11 to 20 of about 441,552 (301)
Detecting p53 Isoforms at Protein Level
, 2012 The human p53 protein isoforms are expressed in several cell lines and modulate p53 tumor suppressor -activity, mainly through modulation of gene expression (1-4). Thus, identifying the pattern of p53 isoforms expression in cell lines is a key step for future studies of the p53 network (5).
Marcel, Virginie +5 more
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Down‐regulation of wheat Rubisco activase isoforms expression by virus‐induced gene silencing [PDF]
Plant DirectRubisco activase (Rca) is an essential photosynthetic enzyme that removes inhibitors from the catalytic sites of the carboxylating enzyme Rubisco. In wheat, Rca is composed of one longer 46 kDa α‐isoform and two shorter 42 kDa β‐isoforms encoded by the ...
Juan Alejandro Perdomo +4 more
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Protein interaction network of alternatively spliced NudCD1 isoforms
Scientific Reports, 2017 NudCD1, also known as CML66 or OVA66, is a protein initially identified as overexpressed in patients with chronic myelogenous leukemia. The mRNA of NudCD1 is expressed in heart and testis of normal tissues, and is overexpressed in several cancers ...
Patrick Asselin-Mullen +5 more
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Alternative splicing in ABA signaling during seed germination
Frontiers in Plant Science, 2023 Seed germination is an essential step in a plant’s life cycle. It is controlled by complex physiological, biochemical, and molecular mechanisms and external factors.
Ewa Sybilska, Agata Daszkowska-Golec
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RNA Biology, 2022 Endothelial cells (ECs) comprise the lumenal lining of all blood vessels and are critical for the functioning of the cardiovascular system. Their phenotypes can be modulated by alternative splicing of RNA to produce distinct protein isoforms.
Madison M. Mehlferber +9 more
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On the Occurrence and Multimerization of Two-Polypeptide Phage Endolysins Encoded in Single Genes
Microbiology Spectrum, 2022 Bacteriophages (phages) and other viruses are extremely efficient in packing their genetic information, with several described cases of overlapping genes encoded in different open reading frames (ORFs).
Daniela Pinto +7 more
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The Isoforms of the p53 Protein [PDF]
Cold Spring Harbor Perspectives in Biology, 2009 p53 is a transcription factor with a key role in the maintenance of genetic stability and therefore preventing cancer formation. It belongs to a family of genes composed of p53, p63, and p73. The p63 and p73 genes have a dual gene structure with an internal promoter in intron-3 and together with alternative splicing, can express 6 and 29 mRNA variants,
Khoury, Marie P. +1 more
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Characteristics of Human OAS1 Isoform Proteins [PDF]
Viruses, 2020 The human OAS1 (hOAS1) gene produces multiple possible isoforms due to alternative splicing events and sequence variation among individuals, some of which affect splicing. The unique C-terminal sequences of the hOAS1 isoforms could differentially affect synthetase activity, protein stability, protein partner interactions and/or cellular localization ...
Han Di, Husni Elbahesh, Margo A. Brinton
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Plant Proteoforms Under Environmental Stress: Functional Proteins Arising From a Single Gene
Frontiers in Plant Science, 2021 Proteins are directly involved in plant phenotypic response to ever changing environmental conditions. The ability to produce multiple mature functional proteins, i.e., proteoforms, from a single gene sequence represents an efficient tool ensuring the ...
Klára Kosová +4 more
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Cells, 2023 Synaptopodin-2 (SYNPO2) is a protein associated with the Z-disc in striated muscle cells. It interacts with α-actinin and filamin C, playing a role in Z-disc maintenance under stress by chaperone-assisted selective autophagy (CASA).
Keerthika Lohanadan +11 more
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