Results 41 to 50 of about 407,396 (256)
The carbohydrates of the isoforms of three avian riboflavin‐binding proteins [PDF]
European Journal of Biochemistry, 1999 The carbohydrate chains of nine isoforms of chicken egg‐white riboflavin‐binding protein (RfBP) and six isoforms each of quail egg‐white and yolk RfBP have been structurally characterized. The two N‐glycosylation sites, Asn36 and Asn147, of the most abundant isoform of each of the three proteins were analyzed in further detail leading to the ...
A. Amoresano +5 more
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BMC Neurology, 2018 Background Post-translational modifications (PTMs) generate a tremendous protein diversity from the ~ 20,000 protein-coding genes of the human genome. In chronic pain conditions, exposure to pathological processes in the central nervous system could lead
Emmanuel Bäckryd +3 more
doaj +1 more source
Protein Binding to mRNA 3′ Isoforms
Current Protocols in Molecular Biology, 2019 AbstractHere we describe CLIP‐READS, a technique that combines elements of crosslinking and immunoprecipitation (CLIP) and 3′ region extraction and deep sequencing (READS), to provide a genome‐wide map of mRNA 3′ isoform binding by a given messenger ribonucleoprotein (mRNP). In CLIP‐READS, cells are grown to logarithmic phase and are irradiated with UV
Joseph V, Geisberg, Zarmik, Moqtaderi
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Analysis of Intact Protein Isoforms by Mass Spectrometry [PDF]
Journal of Biological Chemistry, 2011 The diverse proteome of an organism arises from such events as single nucleotide substitutions at the DNA level, different RNA processing, and dynamic enzymatic post-translational modifications. This minireview focuses on the measurement of intact proteins to describe the diversity found in proteomes.
Jeremiah D, Tipton +5 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Dermatology Reports, 2010 14-3-3 is a highly conserved protein involved in a number of cellular processes including cell signalling, cell cycle regulation and gene transcription. Seven isoforms of the protein have been identified; β, γ, ε, ζ, η, σ and τ. The expression profile of
Line Raaby +4 more
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An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Down‐regulation of wheat Rubisco activase isoforms expression by virus‐induced gene silencing
Plant DirectRubisco activase (Rca) is an essential photosynthetic enzyme that removes inhibitors from the catalytic sites of the carboxylating enzyme Rubisco. In wheat, Rca is composed of one longer 46 kDa α‐isoform and two shorter 42 kDa β‐isoforms encoded by the ...
Juan Alejandro Perdomo +4 more
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Trafficking of the cellular isoform of the prion protein
Biomedicine & Pharmacotherapy, 1999 Transmissible spongiform encephalopathies form a group of fatal neurodegenerative disorders that have the unique property of being infectious, sporadic or genetic in origin. Although the nature of the responsible agent of these diseases is uncertain, it is clear that a protein called PrPSc has a central role in their pathology.
S, Lehmann, O, Milhavet, A, Mangé
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FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source