Results 1 to 10 of about 357,361 (264)
suPAR, a Circulating Kidney Disease Factor
Frontiers in Medicine, 2021 Urokinase plasminogen activator receptor (uPAR) is a multifaceted, GPI-anchored three-domain protein. Release of the receptor results in variable levels of soluble uPAR (suPAR) in the blood circulation.
Changli Wei +3 more
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Alternatively Splicing Interactomes Identify Novel Isoform-Specific Partners for NSD2
Frontiers in Cell and Developmental Biology, 2021 Nuclear receptor SET domain protein (NSD2) plays a fundamental role in the pathogenesis of Wolf–Hirschhorn Syndrome (WHS) and is overexpressed in multiple human myelomas, but its protein–protein interaction (PPI) patterns, particularly at the isoform ...
Weidi Wang +8 more
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Exploring the Significance of the Exon 4-Skipping Isoform of the ZNF217 Oncogene in Breast Cancer
Frontiers in Oncology, 2021 Oncogene alternative splicing events can create distinct functional transcripts that offer new candidate prognostic biomarkers for breast cancer.
Aurélie Bellanger +22 more
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IIIDB: a database for isoform-isoform interactions and isoform network modules [PDF]
BMC Genomics, 2015 Protein-protein interactions (PPIs) are key to understanding diverse cellular processes and disease mechanisms. However, current PPI databases only provide low-resolution knowledge of PPIs, in the sense that "proteins" of currently known PPIs generally refer to "genes." It is known that alternative splicing often impacts PPI by either directly ...
Yu-Ting Tseng +6 more
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Physiological and Transcriptome Indicators of Salt Tolerance in Wild and Cultivated Barley
Frontiers in Plant Science, 2022 Barley is used as a model cereal to decipher salt tolerance mechanisms due to its simpler genome than wheat and enhanced salt tolerance compared to rice and wheat.
Narges Gharaghanipor +3 more
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Isoform Age - Splice Isoform Profiling Using Long-Read Technologies
Frontiers in Molecular Biosciences, 2021 Alternative splicing (AS) of RNA is a key mechanism that results in the expression of multiple transcript isoforms from single genes and leads to an increase in the complexity of both the transcriptome and proteome.
Ricardo De Paoli-Iseppi +2 more
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Ukrainian Journal of Veterinary Sciences, 2021 According to statistics, in modern veterinary practice, the percentage of muscle injuries among sport and working animals ranges from 40–70% of sports injuries.
N. V. STADNYK +4 more
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A Single-Subject Method to Detect Pathways Enriched With Alternatively Spliced Genes
Frontiers in Genetics, 2019 RNA-Sequencing data offers an opportunity to enable precision medicine, but most methods rely on gene expression alone. To date, no methodology exists to identify and interpret alternative splicing patterns within pathways for an individual patient. This
Alfred Grant Schissler +11 more
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A novel splice variant of the human MSTN gene encodes a myostatin‐specific myostatin inhibitor
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Myostatin, encoded by the MSTN gene comprising 3 exons, is a potent negative regulator of skeletal muscle growth. Although a variety of myostatin inhibitors have been invented for increasing muscle mass in muscle wasting diseases, no effective
Kazuhiro Maeta +3 more
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Modulation of the Apoptosis Gene Bcl-x Function Through Alternative Splicing
Frontiers in Genetics, 2019 Apoptosis plays a vital role in cell homeostasis during development and disease. Bcl-x, a member of the Bcl-2 family of proteins, is a mitochondrial transmembrane protein that functions to regulate the intrinsic apoptosis pathway. An alternative splicing
Megan Stevens, Sebastian Oltean
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