Results 21 to 30 of about 357,361 (264)

Fibronectin Isoforms in Megakaryocytes [PDF]

Stem Cells, 1996
Our studies have shown that megakaryocytes (MK) can synthesize fibronectin (FN) and alternatively spliced fibronectin, FN EIIIB. FN EIIIB is primarily present in embryonic, proliferating and migrating cells, and thought to be important for cell maturation.
P K, Schick, C M, Wojensk, V, Bennett, L, Denisova   +3 more
openaire   +2 more sources

Gestation changes sodium pump isoform expression, leading to changes in ouabain sensitivity, contractility, and intracellular calcium in rat uterus

Physiological Reports, 2017
Developmental and tissue‐specific differences in isoforms allow Na+, K+‐ATPase function to be tightly regulated, as they control sensitivity to ions and inhibitors.
Rachel V. Floyd, Ali Mobasheri, Susan Wray   +2 more
doaj   +1 more source

Biological impact of the TSH-beta splice variant in health and disease

Frontiers in Immunology, 2014
Thyroid stimulating hormone (TSH), a glycoprotein hormone composed of alpha and beta chains, is produced by thryrotrope cells of the anterior pituitary.
John R. Klein
doaj   +1 more source

A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

eLife, 2023
Alternative polyadenylation (APA) generates mRNA isoforms and diversifies gene expression. Here we report the discovery that the mTORC1 signaling pathway balances the expression of two Trim9/TRIM9 isoforms through APA regulation in human and mouse.
R Samuel Herron, Alexander K Kunisky, Jessica R Madden, Vivian I Anyaeche, May Z Maung, Hun-Way Hwang   +5 more
doaj   +1 more source

FOXO family isoforms

Cell Death & Disease, 2023
AbstractFOXO family of proteins are transcription factors involved in many physiological and pathological processes including cellular homeostasis, stem cell maintenance, cancer, metabolic, and cardiovascular diseases. Genetic evidence has been accumulating to suggest a prominent role of FOXOs in lifespan regulation in animal systems from hydra, C ...
Santos, Bruno F, Grenho, Inês, Martel, Paulo, Ferreira, Bibiana, Link, Wolfgang   +4 more
openaire   +5 more sources

Nanopore long-read RNAseq reveals transcriptional variations in citrus species

Frontiers in Plant Science, 2023
The number of studies on plant transcriptomes using ONT RNAseq technology is rapidly increasing in recent. It is a powerful method to decipher transcriptomic complexity, particularly alternative splicing (AS) event detection.
Xiao-Li Hu, Xiao-Li Hu, Congjun You, Congjun You, Kaikai Zhu, Xiaolong Li, Xiaolong Li, Jinli Gong, Jinli Gong, Haijie Ma, Haijie Ma, Xuepeng Sun, Xuepeng Sun   +12 more
doaj   +1 more source

IDEIS: a tool to identify PTPRC/CD45 isoforms from single-cell transcriptomic data

Frontiers in Immunology
Single-cell RNA sequencing (scRNA-seq) methods are widely used in life sciences, including immunology. Typical scRNA-seq analysis pipelines quantify the abundance of particular transcripts without accounting for alternative splicing.
Juraj Michalik, Veronika Niederlova, Ondrej Stepanek   +2 more
doaj   +1 more source

Generation and characterization of LPA-KIV9, a murine monoclonal antibody binding a single site on apolipoprotein (a)

Journal of Lipid Research, 2020
Lipoprotein (a) [Lp(a)] is a risk factor for CVD and a target of therapy, but Lp(a) measurements are not globally standardized. Commercially available assays generally use polyclonal antibodies that detect multiple sites within the kringle (K)IV2 repeat ...
Ayelet Gonen, Xiaohong Yang, Calvin Yeang, Elena Alekseeva, Marlys Koschinsky, Joseph L. Witztum, Michael Boffa, Sotirios Tsimikas   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Laminin isoforms and lung development: All isoforms are not equal

Developmental Biology, 2006
Laminins are a major component of basement membranes. Each laminin molecule is a heterotrimeric glycoprotein composed of one alpha, one beta, and one gamma chain. Fifteen laminin isoforms exist, assembled from various combinations of 5alpha, 3beta, and 3gamma chains. The embryonic lung has abundant laminin isoforms.
Nguyen, Nguyet M., Senior, Robert M.
openaire   +2 more sources