Results 41 to 50 of about 357,361 (264)

Expression, Purification and Characterization of a Novel Rusticyanin from the Psychrotolerant Acidithiobacillus ferrivorans

Separations, 2023
Rusticyanin plays a crucial role in ferrous oxidation of sulfide minerals during bioleaching for industrial metal extraction. Diverse isoforms of rusticyanin have been found, but until now, except for type-A rusticyanin, other isoforms or sources of ...
Yuandong Liu, Lixiang Chen, Xiangdong Shangguan, Jingying Ouyang, Jiayu He, Kan Wang, Yan Tong, Runlan Yu, Weimin Zeng, Xueling Wu, Li Shen, Guanzhou Qiu   +11 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Assessing long-distance RNA sequence connectivity via RNA-templated DNA–DNA ligation

eLife, 2015
Many RNAs, including pre-mRNAs and long non-coding RNAs, can be thousands of nucleotides long and undergo complex post-transcriptional processing. Multiple sites of alternative splicing within a single gene exponentially increase the number of possible ...
Christian K Roy, Sara Olson, Brenton R Graveley, Phillip D Zamore, Melissa J Moore   +4 more
doaj   +1 more source

CRISPR/Cas9 Knock-Out in Primary Neonatal and Adult Cardiomyocytes Reveals Distinct cAMP Dynamics Regulation by Various PDE2A and PDE3A Isoforms

Cells, 2023
Cyclic nucleotide phosphodiesterases 2A (PDE2A) and PDE3A play an important role in the regulation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP)-to-cAMP crosstalk. Each of these PDEs has up to three distinct isoforms.
Egor B. Skryabin, Kirstie A. De Jong, Hariharan Subramanian, Nadja I. Bork, Alexander Froese, Boris V. Skryabin, Viacheslav O. Nikolaev   +6 more
doaj   +1 more source

Tropomyosin isoforms and reagents [PDF]

BioArchitecture, 2011
Tropomyosins are rod-like dimers which form head-to-tail polymers along the length of actin filaments and regulate the access of actin binding proteins to the filaments.1 The diversity of tropomyosin isoforms, over 40 in mammals, and their role in an increasing number of biological processes presents a challenge both to experienced researchers and ...
Galina, Schevzov, Shane P, Whittaker, Thomas, Fath, Jim Jc, Lin, Peter W, Gunning   +4 more
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A proteogenomic atlas of the human neural retina

Frontiers in Genetics
The human neural retina is a complex tissue with abundant alternative splicing and more than 10% of genetic variants linked to inherited retinal diseases (IRDs) alter splicing.
Tabea V. Riepe, Tabea V. Riepe, Tabea V. Riepe, Tabea V. Riepe, Merel Stemerdink, Renee Salz, Alfredo Dueñas Rey, Alfredo Dueñas Rey, Suzanne E. de Bruijn, Suzanne E. de Bruijn, Erica Boonen, Erica Boonen, Erica Boonen, Tomasz Z. Tomkiewicz, Tomasz Z. Tomkiewicz, Tomasz Z. Tomkiewicz, Michael Kwint, Jolein Gloerich, Hans J. C. T. Wessels, Emma Delanote, Emma Delanote, Elfride De Baere, Elfride De Baere, Filip van Nieuwerburgh, Sarah De Keulenaer, Barbara Ferrari, Stefano Ferrari, Frauke Coppieters, Frauke Coppieters, Frauke Coppieters, Frans P. M. Cremers, Frans P. M. Cremers, Frans P. M. Cremers, Erwin van Wyk, Susanne Roosing, Susanne Roosing, Susanne Roosing, Erik de Vrieze, Peter A. C. ‘t Hoen   +38 more
doaj   +1 more source

PMEPA1 Gene Isoforms: A Potential Biomarker and Therapeutic Target in Prostate Cancer

Biomolecules, 2020
The identification of prostate transmembrane protein androgen induced 1 (PMEPA1), an androgen responsive gene, came initially from the studies of androgen regulatory gene networks in prostate cancer.
Shashwat Sharad, Albert Dobi, Shiv Srivastava, Alagarsamy Srinivasan, Hua Li   +4 more
doaj   +1 more source

DASES: a database of alternative splicing for esophageal squamous cell carcinoma

Frontiers in Genetics, 2023
Esophageal carcinoma ranks as the sixth leading cause of cancer-related mortality globally, with esophageal squamous cell carcinoma (ESCC) being particularly prevalent among Asian populations.
Yilong Chen, Yilong Chen, Yalan Kuang, Yalan Kuang, Siyuan Luan, Yongsan Yang, Yongsan Yang, Zhiye Ying, Zhiye Ying, Chunyang Li, Chunyang Li, Jinhang Gao, Jinhang Gao, Yong Yuan, Haopeng Yu, Haopeng Yu   +15 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source