Results 21 to 30 of about 407,396 (256)

Isoform Divergence of the Filamin Family of Proteins [PDF]

Molecular Biology and Evolution, 2009
The vertebrate filamin family (A, B, and C) is part of the spectrin family of actin cross-linking proteins. Family members share high sequence similarity (>64%) and have both common and isoform-distinct functionalities. To identify the basis for isoform-specific functionality, we perform an evolutionary trace of chordate filamin at the granularity of ...
Barry A, Kesner, Sharon L, Milgram, Brenda R S, Temple, Nikolay V, Dokholyan   +3 more
openaire   +2 more sources

Enhanced protein isoform characterization through long-read proteogenomics

Genome Biology, 2022
Background The detection of physiologically relevant protein isoforms encoded by the human genome is critical to biomedicine. Mass spectrometry (MS)-based proteomics is the preeminent method for protein detection, but isoform-resolved proteomic analysis ...
Rachel M. Miller, Ben T. Jordan, Madison M. Mehlferber, Erin D. Jeffery, Christina Chatzipantsiou, Simi Kaur, Robert J. Millikin, Yunxiang Dai, Simone Tiberi, Peter J. Castaldi, Michael R. Shortreed, Chance John Luckey, Ana Conesa, Lloyd M. Smith, Anne Deslattes Mays, Gloria M. Sheynkman   +15 more
doaj   +1 more source

Identification and functional comparison of novel alternatively spliced isoforms of human YAP

FEBS Open Bio, 2023
As a key effector of the Hippo pathway, yes‐associated protein (YAP) is a major regulator of cell proliferation and apoptosis. In this study, 23 hYAP isoforms were identified in HEK293 cells, with 14 isoforms being reported for the first time.
Lianlian Liu, Junlei Zhang, Jiaqi Wang, Yanping Tian, Jiali Wang, Yixiao Xu, Yuda Cheng, Meng Yu, Jiangjun Wang, Yi Yang, Xueyue Wang, Ran Yang, Wei Wu, Chen Zhang, Yan Hu, Rui Jian, Lan Xiao, Yan Ruan   +17 more
doaj   +1 more source

Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing. [PDF]

PLoS ONE, 2011
BackgroundTranscription factor 4 (TCF4 alias ITF2, E2-2, ME2 or SEF2) is a ubiquitous class A basic helix-loop-helix protein that binds to E-box DNA sequences (CANNTG).
Mari Sepp, Kaja Kannike, Ave Eesmaa, Mari Urb, Tõnis Timmusk   +4 more
doaj   +1 more source

Structure-guided isoform identification for the human transcriptome

eLife, 2022
Recently developed methods to predict three-dimensional protein structure with high accuracy have opened new avenues for genome and proteome research. We explore a new hypothesis in genome annotation, namely whether computationally predicted structures ...
Markus J Sommer, Sooyoung Cha, Ales Varabyou, Natalia Rincon, Sukhwan Park, Ilia Minkin, Mihaela Pertea, Martin Steinegger, Steven L Salzberg   +8 more
doaj   +1 more source

Differential Expression of IL-17RC Isoforms in Androgen-Dependent and Androgen-Independent Prostate Cancers

Neoplasia: An International Journal for Oncology Research, 2007
IL-17RC (interleukin-17 receptor-like) gene codes for a transmembrane protein, the full length of which inhibits apoptosis in prostate cancer cells. IL-17RC gene transcribes over a dozen different splice variants of mRNA. However, it is not known whether
Zongbing You, Ying Dong, Xiangtian Kong, Yi Zhang, Robert L. Vessella, Jonathan Melamed   +5 more
doaj   +1 more source

Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls.

PLoS ONE, 2023
Advancements in deep plasma proteomics are enabling high-resolution measurement of plasma proteoforms, which may reveal a rich source of novel biomarkers previously concealed by aggregated protein methods.
Margaret K R Donovan, Yingxiang Huang, John E Blume, Jian Wang, Daniel Hornburg, Shadi Ferdosi, Iman Mohtashemi, Sangtae Kim, Marwin Ko, Ryan W Benz, Theodore L Platt, Serafim Batzoglou, Luis A Diaz, Omid C Farokhzad, Asim Siddiqui   +14 more
doaj   +2 more sources

Discovering human protein diversity

Macedonian Journal of Chemistry and Chemical Engineering, 2008
Current emphasis on discovering and correlating human genetic variations lays the foundation for future studies of human protein diversity. Protein posttranslational processing, along with the translation of genetic variations, results in a complex ...
Dobrin Nedelkov
doaj   +1 more source

GFAP Alternative Splicing and the Relevance for Disease – A Focus on Diffuse Gliomas

ASN Neuro, 2022
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is characteristic for astrocytes and neural stem cells, and their malignant analogues in glioma.
Jessy V. van Asperen, Pierre A.J.T. Robe, Elly M. Hol   +2 more
doaj   +1 more source

Splice-mediated Variants of Proteins (SpliVaP) – data and characterization of changes in signatures among protein isoforms due to alternative splicing

BMC Genomics, 2008
Background It is often the case that mammalian genes are alternatively spliced; the resulting alternate transcripts often encode protein isoforms that differ in amino acid sequences. Changes among the protein isoforms can alter the cellular properties of
Thanaraj Thangavel, Orsini Massimiliano, Floris Matteo   +2 more
doaj   +1 more source