Results 21 to 30 of about 441,552 (301)
Isoforms of the class II transactivator protein [PDF]
International Immunology, 2002 The class II transactivator (CIITA) controls both the constitutive and IFN-gamma inducible expression of HLA-D genes. In addition, through the squelching of another transactivator CREB-binding protein, CIITA was more recently shown to have a wider cellular function, including cell cycle control or cellular response to IFN-gamma and IL-4.
Barbieri G +10 more
openaire +7 more sources
Efficient Detection of the Alternative Spliced Human Proteome Using Translatome Sequencing
Frontiers in Molecular Biosciences, 2022 Alternative splicing (AS) isoforms create numerous proteoforms, expanding the complexity of the genome. Highly similar sequences, incomplete reference databases and the insufficient sequence coverage of mass spectrometry limit the identification of AS ...
Chun Wu +11 more
doaj +1 more source
Isoform Divergence of the Filamin Family of Proteins [PDF]
Molecular Biology and Evolution, 2009 The vertebrate filamin family (A, B, and C) is part of the spectrin family of actin cross-linking proteins. Family members share high sequence similarity (>64%) and have both common and isoform-distinct functionalities. To identify the basis for isoform-specific functionality, we perform an evolutionary trace of chordate filamin at the granularity of ...
Barry A, Kesner +3 more
openaire +2 more sources
Frontiers in Microbiology, 2023 The largest family of transmembrane receptors are G-protein-coupled receptors (GPCRs). These receptors respond to perceived environmental signals and infect their host plants. Family A of the GPCR includes opsin.
Marzieh Mohri +3 more
doaj +1 more source
Identification and functional comparison of novel alternatively spliced isoforms of human YAP
FEBS Open Bio, 2023 As a key effector of the Hippo pathway, yes‐associated protein (YAP) is a major regulator of cell proliferation and apoptosis. In this study, 23 hYAP isoforms were identified in HEK293 cells, with 14 isoforms being reported for the first time.
Lianlian Liu +17 more
doaj +1 more source
PML isoforms in response to arsenic: high-resolution analysis of PML body structure and degradation [PDF]
, 2014 Arsenic is a clinically effective treatment for acute promyelocytic leukaemia (APL) in which the promyelocytic leukaemia (PML) protein is fused to retinoic receptor alpha (RARα).
Hands, K.J. +7 more
core +1 more source
Enhanced protein isoform characterization through long-read proteogenomics
Genome Biology, 2022 Background The detection of physiologically relevant protein isoforms encoded by the human genome is critical to biomedicine. Mass spectrometry (MS)-based proteomics is the preeminent method for protein detection, but isoform-resolved proteomic analysis ...
Rachel M. Miller +15 more
doaj +1 more source
Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing. [PDF]
PLoS ONE, 2011 BackgroundTranscription factor 4 (TCF4 alias ITF2, E2-2, ME2 or SEF2) is a ubiquitous class A basic helix-loop-helix protein that binds to E-box DNA sequences (CANNTG).
Mari Sepp +4 more
doaj +1 more source
Expression and modulation of CD44 variant isoforms in humans [PDF]
, 1994 CD44 is a ubiquitous surface molecule that exists as a number of isoforms, generated by alternative splicing of 10 "variant" exons. Little is known about the expression and function of the variant isoforms, except that certain isoforms may play a role in
Mackay, C. R. +11 more
core +1 more source
Structure-guided isoform identification for the human transcriptome
eLife, 2022 Recently developed methods to predict three-dimensional protein structure with high accuracy have opened new avenues for genome and proteome research. We explore a new hypothesis in genome annotation, namely whether computationally predicted structures ...
Markus J Sommer +8 more
doaj +1 more source