Results 31 to 40 of about 407,396 (256)

The FU gene and its possible protein isoforms [PDF]

BMC Genomics, 2004
Abstract Background FU is the human homologue of the Drosophila gene fused whose product fused is a positive regulator of the transcription factor Cubitus interruptus (Ci). Thus, FU may act as a regulator of the human counterparts of Ci, the GLI transcription factors.
Østerlund, Torben, Everman, David B., Betz, Regina C., Mosca, Monica, Nöthen, Markus M., Schwartz, Charles E., Zaphiropoulos, Peter G., Toftgård, Rune   +7 more
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Protein isoforms. Origin, structure and functions. [PDF]

Biopolymers and Cell, 2017
Many proteins in mammalian organism exist as isoforms. These isoforms can be encoded by different genes or produced by alternative splicing of one gene. Despite rapid instrumental progress in the isoform identification, the reasons for their existence and specific functions remain largely unknown.
openaire   +2 more sources

Identification and classification of innexin gene transcripts in the central nervous system of the terrestrial slug Limax valentianus.

PLoS ONE, 2021
Intercellular gap junction channels and single-membrane channels have been reported to regulate electrical synapse and the brain function. Innexin is known as a gap junction-related protein in invertebrates and is involved in the formation of ...
Hisayo Sadamoto, Hironobu Takahashi, Suguru Kobayashi, Hirooki Kondoh, Hiroshi Tokumaru   +4 more
doaj   +1 more source

The Genetic Regulation of Alternative Splicing in Populus deltoides

Frontiers in Plant Science, 2020
Alternative splicing (AS) is a mechanism of regulation of the proteome via enabling the production of multiple mRNAs from a single gene. To date, the dynamics of AS and its effects on the protein sequences of individuals in a large and genetically ...
Jerald D. Noble, Kelly M. Balmant, Christopher Dervinis, Gustavo de los Campos, Gustavo de los Campos, Márcio F. R. Resende, Márcio F. R. Resende, Matias Kirst, Matias Kirst, Matias Kirst, William Brad Barbazuk, William Brad Barbazuk, William Brad Barbazuk, William Brad Barbazuk   +13 more
doaj   +1 more source

The Difference in Structural States between Canonical Proteins and Their Isoforms Established by Proteome-Wide Bioinformatics Analysis

Biomolecules, 2022
Alternative splicing is an important means of generating the protein diversity necessary for cellular functions. Hence, there is a growing interest in assessing the structural and functional impact of alternative protein isoforms. Typically, experimental
Zarifa Osmanli, Theo Falgarone, Turkan Samadova, Gudrun Aldrian, Jeremy Leclercq, Ilham Shahmuradov, Andrey V. Kajava   +6 more
doaj   +1 more source

Isoforms of contractile proteins

Progress in Biophysics and Molecular Biology, 1987
Although the mechanism of muscle contraction is essentially the same and the properties ofindividuai contractile proteins such as molecular mass and the overall structure are similar in different types of muscles, more subtle differences were found when muscles of different sources were investigated by using specific and sensitive biochemical ...
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Diagnostic utility of prostate health index density prior to MRI-ultrasound fusion targeted biopsy

Exploration of Targeted Anti-tumor Therapy
Aim: Prostate biopsy can be prone to complications and thus should be avoided when unnecessary. Although the combination of magnetic resonance imaging (MRI), the prostate health index (PHI), and PHI density (PHID) has been shown to improve detection of ...
Benjamin H. Press, Soum D. Lokeshwar, Lindsey Webb, Ghazal Khajir, Shayan Smani, Olamide Olawoyin, Mursal Gardezi, Syed N. Rahman, Michael S. Leapman, Preston C. Sprenkle   +9 more
doaj   +1 more source

Protein interaction network of alternatively spliced NudCD1 isoforms

Scientific Reports, 2017
NudCD1, also known as CML66 or OVA66, is a protein initially identified as overexpressed in patients with chronic myelogenous leukemia. The mRNA of NudCD1 is expressed in heart and testis of normal tissues, and is overexpressed in several cancers ...
Patrick Asselin-Mullen, Anaïs Chauvin, Marie-Line Dubois, Romain Drissi, Dominique Lévesque, François-Michel Boisvert   +5 more
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The Opposite Functions of CD30 Ligand Isoforms

Current Issues in Molecular Biology
TNFSF8/CD30 ligand is a TNF superfamily member expressed on several major immune cell types, including activated monocytes, B, and T cells. The signaling of CD30 ligand through its cognate CD30 receptor has been shown to have effects on cell ...
Ignat Printsev, Elyas Alalli, Janine Bilsborough   +2 more
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Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome

Cell Reports, 2019
Summary: The protein-level translational status and function of many alternative splicing events remain poorly understood. We use an RNA sequencing (RNA-seq)-guided proteomics method to identify protein alternative splicing isoforms in the human proteome
Edward Lau, Yu Han, Damon R. Williams, Cody T. Thomas, Rajani Shrestha, Joseph C. Wu, Maggie P.Y. Lam   +6 more
doaj   +1 more source