Results 31 to 40 of about 441,552 (301)

Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina:insights into X-linked Retinitis Pigmentosa and associated ciliopathies [PDF]

, 2008
Mutations in the cilia-centrosomal protein Retinitis Pigmentosa GTPase Regulator (RPGR) are a frequent cause of retinal degeneration. The RPGR gene undergoes complex alternative splicing and encodes multiple protein isoforms. To elucidate the function of
Hurd, Toby W, Behnam, Babak, Margolis, Ben, Khanna, Hemant, Parapuram, Sunil K., Hurd, Toby W., He, Shirley, Parapuram, Sunil K, Swaroop, Anand   +8 more
core   +1 more source

Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics [PDF]

, 2014
Vascular endothelial growth factor-A (VEGF) is produced by most cancer cells as multiple isoforms, which display distinct biological activities. VEGF plays an undisputed role in tumour growth, vascularisation and metastasis; nevertheless the functions of
Reyes-Aldasoro, Constantino C., Steele, A.J., Constantino C Reyes-Aldasoro, Harris Sheila, English William R., English, W. R., Kanthou, Chryso, Diane V Lefley, Reyes-Aldasoro, C.C., Sheila Harris (77307), Reyes-Aldasoro Constantino C., Lefley, D. V., Dos Santos, S. A., Andrew J Steele, English, William R., Dachs, G. U., English, W.R., Steele Andrew J., Sheila Harris, Dachs Gabi U., Greco, Olga, Gillian M. Tozer (167783), Claudia Coralli-Foxon, Kanthou Chryso, Reyes-Aldasoro, C. C., William R English, Steele, Andrew J., Tozer, G. M., Gabi U Dachs, Coralli-Foxon, Claudia, Olga Greco (614634), Harris, S., Olga Greco, Andrew J. Steele (614632), Sofia A. Dos Santos (614635), Dachs, G.U., Dos Santos, S.A., Claudia Coralli-Foxon (614633), Harris, Sheila, Sofia A Dos Santos, Coralli-Foxon Claudia, Greco Olga, Tozer Gillian M., Chryso Kanthou, Gillian M Tozer, Tozer, Gillian M., William R. English (184202), Dos Santos Sofia A., Kanthou, C., Lefley, Diane V., Dos Santos, Sofia A., Chryso Kanthou (22774), Greco, O., Gabi U. Dachs (614630), Steele, A. J., Lefley, D.V., Diane V. Lefley (614631), Dachs, Gabi U., Constantino C. Reyes-Aldasoro (324791), Lefley Diane V., Coralli-Foxon, C., Tozer, G.M.   +61 more
core   +1 more source

Differential Expression of IL-17RC Isoforms in Androgen-Dependent and Androgen-Independent Prostate Cancers

Neoplasia: An International Journal for Oncology Research, 2007
IL-17RC (interleukin-17 receptor-like) gene codes for a transmembrane protein, the full length of which inhibits apoptosis in prostate cancer cells. IL-17RC gene transcribes over a dozen different splice variants of mRNA. However, it is not known whether
Zongbing You, Ying Dong, Xiangtian Kong, Yi Zhang, Robert L. Vessella, Jonathan Melamed   +5 more
doaj   +1 more source

Prion protein in the cerebrospinal fluid of healthy and naturally scrapie-affected sheep [PDF]

, 2006
The aim of this study was to characterize the cerebrospinal fluid (CSF) prion protein (PrP) of healthy and naturally scrapie-affected sheep. The soluble form of CSF PrPC immunoblotted with an anti-octarepeat and an anti-C terminus mAb showed two isoforms
Vé Ronique Gayrard, Moudjou, Mohammed, Gayrard-Troy, Véronique, V., Pierre-Louis Toutain, Mohammed Moudjou, Chantal Imbs, Viguié, Catherine, Toutain, Pierre-Louis, Imbs, Chantal, Moudjou, Mohammed, M., Catherine Viguié, Nicole Picard-Hagen, Picard-Hagen, Nicole, Gayrard, Véronique   +13 more
core   +1 more source

The FU gene and its possible protein isoforms [PDF]

BMC Genomics, 2004
Abstract Background FU is the human homologue of the Drosophila gene fused whose product fused is a positive regulator of the transcription factor Cubitus interruptus (Ci). Thus, FU may act as a regulator of the human counterparts of Ci, the GLI transcription factors.
Østerlund, Torben, Everman, David B., Betz, Regina C., Mosca, Monica, Nöthen, Markus M., Schwartz, Charles E., Zaphiropoulos, Peter G., Toftgård, Rune   +7 more
openaire   +4 more sources

The novel MAPT mutation K298E:mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons [PDF]

, 2013
Frontotemporal lobar degeneration (FTLD) is the one of the most frequent neurodegenerative disorders characterized by behavioral and executive impairment, language disorders and motor dysfunction.
Holton, Janice L., Tammaryn Lashley, Treacy, Rebecca, Laura Calo, Michel Goedert, Parmar, Malin,, Muqit, Miratul M. K., Janice L. Holton, Revesz, Tamas, Lashley, Tammaryn, Mariangela Iovino, Tamas Revesz, Robert J. Swingler, Pfisterer, Ulrich, Swingler, Robert J., Malin Parmar, Maria Grazia Spillantini, Calo, Laura, Ulrich Pfisterer, Miratul M. K. Muqit, Parmar, Malin, Spillantini, Maria Grazia, Iovino, Mariangela, Pfisterer, Ulrich,, Lund University., Iovino, Mariaangela, Goedert, Michel, Rebecca Treacy   +27 more
core   +1 more source

Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls.

PLoS ONE, 2023
Advancements in deep plasma proteomics are enabling high-resolution measurement of plasma proteoforms, which may reveal a rich source of novel biomarkers previously concealed by aggregated protein methods.
Margaret K R Donovan, Yingxiang Huang, John E Blume, Jian Wang, Daniel Hornburg, Shadi Ferdosi, Iman Mohtashemi, Sangtae Kim, Marwin Ko, Ryan W Benz, Theodore L Platt, Serafim Batzoglou, Luis A Diaz, Omid C Farokhzad, Asim Siddiqui   +14 more
doaj   +2 more sources

Discovering human protein diversity

Macedonian Journal of Chemistry and Chemical Engineering, 2008
Current emphasis on discovering and correlating human genetic variations lays the foundation for future studies of human protein diversity. Protein posttranslational processing, along with the translation of genetic variations, results in a complex ...
Dobrin Nedelkov
doaj   +1 more source

GFAP Alternative Splicing and the Relevance for Disease – A Focus on Diffuse Gliomas

ASN Neuro, 2022
Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is characteristic for astrocytes and neural stem cells, and their malignant analogues in glioma.
Jessy V. van Asperen, Pierre A.J.T. Robe, Elly M. Hol   +2 more
doaj   +1 more source

Protein isoforms. Origin, structure and functions. [PDF]

Biopolymers and Cell, 2017
Many proteins in mammalian organism exist as isoforms. These isoforms can be encoded by different genes or produced by alternative splicing of one gene. Despite rapid instrumental progress in the isoform identification, the reasons for their existence and specific functions remain largely unknown.
openaire   +2 more sources