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VEGF and VEGF receptors are differentially expressed in chondrocytes
Bone, 2007During long bone development, cartilage replacement by bone is governed in part by angiogenesis. Although it has been demonstrated that vascular endothelial growth factor (VEGF-A) is crucial during endochondral ossification, little is known about the involvement of the other VEGF family members.
Bluteau, G. +6 more
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VEGF signaling: Role in angiogenesis and beyond
Biochimica et biophysica acta. Reviews on cancerAngiogenesis is a crucial process for tissue development, repair, and tumor survival. Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells, promoting neovascularization.
Pallab Shaw +4 more
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International Journal of Biochemistry and Cell Biology, 2019
BACKGROUND We previously reported that co-transplantation of exosomes from hypoxia-preconditioned adipose mesenchymal stem cells (ADSCs) improves the neoangiogenesis and survival of the grafted tissue.
Yudi Han +4 more
semanticscholar +1 more source
BACKGROUND We previously reported that co-transplantation of exosomes from hypoxia-preconditioned adipose mesenchymal stem cells (ADSCs) improves the neoangiogenesis and survival of the grafted tissue.
Yudi Han +4 more
semanticscholar +1 more source
Current biology of VEGF-B and VEGF-C
Current Opinion in Biotechnology, 1999Endothelial growth factors and their receptors may provide important therapeutic tools for the treatment of pathological conditions characterised by defective or aberrant angiogenesis. Vascular endothelial growth factor (VEGF) is pivotal for vasculogenesis and for angiogenesis in normal and pathological conditions.
B, Olofsson +3 more
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Unique signal transduction of the VEGF family members VEGF-A and VEGF-E
Biochemical Society Transactions, 2009Both VEGF (vascular endothelial growth factor)-A and Orf-virus-encoded VEGF-E bind and activate VEGFR (VEGF receptor)-2; however, only VEGF-A binds VEGFR-1. To understand the biological differences between VEGF-A and VEGF-E in vivo, we established transgenic mouse models.
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Neuroscience Research, 2008
In amyotrophic lateral sclerosis (ALS), an adult-onset progressive degeneration of motor neurons occurring as sporadic and familial disease, there is emerging evidence for and against the role of vascular endothelial growth factor (VEGF), an endothelial cell mitogen crucial for angiogenesis, in its etiopathogenesis.
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In amyotrophic lateral sclerosis (ALS), an adult-onset progressive degeneration of motor neurons occurring as sporadic and familial disease, there is emerging evidence for and against the role of vascular endothelial growth factor (VEGF), an endothelial cell mitogen crucial for angiogenesis, in its etiopathogenesis.
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Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics.
Seminars in Cancer Biology, 2017The critical role of angiogenesis in promoting tumor growth and metastasis has been well established scientifically, and consequently blocking this pathway as a therapeutic strategy has demonstrated great clinical success for the treatment of cancer. The
P. Hegde, J. Wallin, C. Mancao
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Molecular Biology of the VEGF and the VEGF Receptor Family
Seminars in Thrombosis and Hemostasis, 2000Vascular endothelial growth factor (VEGF) is the founding member of a still growing family of endothelial cell growth factors. The diverse functions of VEGF and its homologues (PIGF, VEGF-B, VEGF-C, VEGF-D, and VEGF-E) can be explained by their differential binding to the three signaling VEGF receptors.
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[VEGF, anti-vEGF and diseases].
Bulletin de l'Academie nationale de medecine, 2008Angiogenesis is a rapidly growing research field. Most of the important vascular growth factors have been identified in the space of a few years, as well as factors responsible for the diferentiation of arteries, veins and lymphatic vessels. The role of angiogenesis in tumor growth, exsudative retinopathies and some inflammatory diseases has been ...
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