Results 131 to 140 of about 2,608,192 (371)

Modulation of Receptor Tyrosine Kinase Activity through Alternative Splicing of Ligands and Receptors in the VEGF-A/VEGFR Axis

Cells, 2019
Vascular endothelial growth factor A (VEGF-A) signaling is essential for physiological and pathological angiogenesis. Alternative splicing of the VEGF-A pre-mRNA gives rise to a pro-angiogenic family of isoforms with a differing number of amino acids ...
Megan Stevens, Sebastian Oltean
doaj   +1 more source

Fluid Shear‐Controlled Pro/Anti‐Inflammatory Osteomodulatory Construct for Drug‐Free Immune Activation Through Cationic Ion Channel Activation

Advanced Healthcare Materials, EarlyView.
A 3D‐printed PCL scaffold coated with Arginine was laminated with electrospun polyvinyl alcohol (PVA) nanofibers containing cationic cellulose nanocrystals (PVA@cCNC). This created nanoisland‐like regions of aligned and random cCNC‐rich fibers. The composite scaffold, under fluid shear stimulation, modulated macrophage polarization from M1 to M2 ...
Keya Ganguly, Aayushi Randhawa, Sayan Deb Dutta, Jieun Lee, Youjin Seol, Mehran Mohammad Hossein Pour, Tejal V. Patil, Rumi Acharya, Ki‐Taek Lim   +8 more
wiley   +1 more source

Gene expression of vascular endothelial growth factors and their receptors in different variants of the course of multiple myeloma

Терапевтический архив, 2013
AIM: To determine the significance of the angiogenic activity estimated from the gene expression of the vascular endothelial growth factors (VEGFs) VEGF-A, VEGF-C, and VEGF-D and their receptors VEGFR1, VEGFR1s, VEGFR2, and VEGFR3 in the mononuclear cell
A K Golenkov, I V Buravtsova, G A Dudina, T D Lutskaia, T A Mitina, E V Kataeva, A F Karamysheva, E S Kakpakova, Iu A Sablina, A A Stavrovskaia   +9 more
doaj  

Conditioned Media from Mechanically Stimulated Macrophages Upregulate Osteogenic Genes in Human Mesenchymal Stromal Cells

Advanced Healthcare Materials, EarlyView.
Bone fracture healing is a complex, timely orchestrated scenario involving multiple cell types and a plethora of cytokines and regulatory factors. To gain further insight, an in vitro model to a) study macrophage polarization under mechanical load in a fibrin hydrogel and b) subsequently assess the effect of conditioned media derived from macrophages ...
Anne Géraldine Guex, Ursula Menzel, Yann Ladner, Angela R. Armiento, Martin J. Stoddart   +4 more
wiley   +1 more source

Inhibition of VEGF receptors induces pituitary apoplexy: An experimental study in mice. [PDF]

PLoS One, 2023
Sugita Y, Takada S, Tanigaki K, Muraki K, Uemura M, Hojo M, Miyamoto S.   +6 more
europepmc   +1 more source

Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. [PDF]

, 2003
Antagonists of alphavbeta3 and alphavbeta5 disrupt angiogenesis in response to bFGF and VEGF, respectively. Here, we show that these alphav integrins differentially contribute to sustained Ras-extracellular signal-related kinase (Ras-ERK) signaling in ...
Cheresh, David A, Frausto, Ricardo, Hood, John D, Kiosses, William B, Schwartz, Martin A   +4 more
core   +1 more source

Si Inhibited Osteoclastogenesis: The Role of Fe and the Fenton Reaction

Advanced Healthcare Materials, EarlyView.
Silicate (Si) inhibition of osteoclastogenesis, is mediated by Fe. Si chemical interactions with Fe inhibit the Fenton reaction and intercellular ROS availability. This reduction in ROS availability inhibits osteoclastogenesis. The addition of Fe, in Si‐inhibited osteoclast cultures, restores the Fenton reaction, and osteoclastogenesis.
Yutong Li, Adriana‐Monica Radu, Azadeh Rezaei, Joel Turner, Kaveh Shakib, Akiko Obata, Toshihiro Kasuga, Gavin Jell   +7 more
wiley   +1 more source

Vascular heterogeneity: VEGF receptors make blood vessels special. [PDF]

J Exp Med, 2022
Li P, Ferrara N.
europepmc   +1 more source

Guided Bone Regeneration Membrane Materials Loaded with Chimeric Nanovesicles Promote Early Bone Defect Regeneration

Advanced Healthcare Materials, EarlyView.
Early bone regeneration is challenged by poor osteogenic microenvironments. We developed a novel guided bone regeneration (GBR) membrane: a plasma‐treated polycaprolactone (PT‐PCL) electrospun nanofiber functionalized with ultrasound sequentially extruded stromal vascular fraction chimeric vesicles (USE‐SCNVs). USE‐SCNVs require less equipment, enhance
Yufan Zhang, Yaqiong Wang, Xiaona Ning, Guichu Yue, Wenhui Zhang, Yicheng Chen, Xuelian Jia, Yu Zhang, Xiao Zhang, Zihan Lu, Simin Zhu, Fuwei Liu, Yong Zhao, Liang Kong   +13 more
wiley   +1 more source

Possible neuroprotective role of P2X2 in the retina of diabetic rats

Diabetology & Metabolic Syndrome, 2018
Background Purinergic receptors are expressed in different tissues including the retina. These receptors are involved in processes like cell growth, proliferation, activation and survival. ATP is the major activator of P2 receptors. In diabetes, there is
Jorge E. Mancini, Gustavo Ortiz, Constanza Potilinstki, Juan P. Salica, Emiliano S. Lopez, J. Oscar Croxatto, Juan E. Gallo   +6 more
doaj   +1 more source