Results 201 to 210 of about 2,650,230 (376)

Phase I/II and Pharmacodynamic Study of Dovitinib (TKI258), an Inhibitor of Fibroblast Growth Factor Receptors and VEGF Receptors, in Patients with Advanced Melanoma

Clinical Cancer Research, 2011
Kevin B. Kim, J. Chesney, D. Robinson, H. Gardner, M. Shi, J. Kirkwood   +5 more
semanticscholar   +1 more source

New Models of Pulmonary Hypertension Based on VEGF Receptor Blockade‐Induced Endothelial Cell Apoptosis [PDF]

, 2012
Mark R. Nicolls, Shiro Mizuno, Laima Tarasevičienė-Stewart, László Farkas, Jennifer I. Drake, Aysar Al Husseini, Jose Gomez‐Arroyo, Norbert F. Voelkel, Harm Jan Bogaard   +8 more
openalex   +1 more source

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang, Jianbo Huang, Shuwei Zhang, Sujiao Cao, Fangxue Du, Liqiang Zhou, Li Qiu, Yuanjiao Tang   +7 more
wiley   +1 more source

Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish.

Proceedings of the National Academy of Sciences of the United States of America, 2006
Laurence D. Covassin, Jacques A Villefranc, Michael C. Kacergis, B. Weinstein, N. Lawson   +4 more
semanticscholar   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source

Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells

Oncogene, 2000
S. Kanno, N. Oda, M. Abe, Y. Terai, Mikito Ito, K. Shitara, K. Tabayashi, M. Shibuya, Yasufumi Sato   +8 more
semanticscholar   +1 more source

Cell-Demanded VEGF Release via Nanocapsules Elicits Different Receptor Activation Dynamics and Enhanced Angiogenesis

, 2016
Suwei Zhu, Tatiana Segura
openalex   +1 more source

Vascular endothelial growth factor (VEGF) impairs the motility and immune function of human mature dendritic cells through the VEGF receptor 2‐RhoA‐cofilin1 pathway [PDF]

, 2019
Jinhua Long, Zuquan Hu, Hui Xue, Yun Wang, Jin Chen, Fuzhou Tang, Jing Zhou, Lina Liu, Wei Qiu, Shichao Zhang, Yan Ouyang, Yuannong Ye, Guoqiang Xu, Long Li, Zhu Zeng   +14 more
openalex   +1 more source

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Risk of Necrotizing Enterocolitis Associated With the Single Nucleotide Polymorphisms VEGF C-2578A, IL-18 C-607A, and IL-4 Receptor α-Chain A-1902G: A Validation Study in a Prospective Multicenter Cohort

, 2020
Rob Moonen, Maurice J. Huizing, Gema E. González-Luis, Giacomo Cavallaro, Fabio Mosca, Eduardo Villamor   +5 more
openalex   +1 more source