Results 211 to 220 of about 2,608,192 (371)

Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells

Journal of Cellular Physiology, 2010
A. Miki, Katsuaki Miki, S. Ueno, Delphine M. Bonnet Wersinger, C. Berlinicke, G. Shaw, S. Usui, Yuxia Wang, D. Zack, P. Campochiaro   +9 more
semanticscholar   +1 more source

Monoclonal antibodies to vascular endothelial growth factor‐D block its interactions with both VEGF receptor‐2 and VEGF receptor‐3 [PDF]

, 2000
Marc G. Achen, Sally Roufail, Teresa Domagała, Bruno Catimel, Edouard C. Nice, Detlef Geleick, Roger Murphy, Andrew M. Scott, Carol Caesar, Taija Mäkinen, Kari Alitalo, Steven A. Stacker   +11 more
openalex   +1 more source

Loss of Fibronectin Fiber Tension in Glioblastoma is Associated with Microvascular Proliferations and Immune Cell Infiltration

Advanced Science, EarlyView.
Researchers discovered that fibronectin fibers lose their tension in specific areas of glioblastoma brain tumors, accumulating in the lumen of proliferating blood vessels and in parenchyma next to infiltrating immune cell clusters. A novel molecular tension probe enables the mapping of fibronectin's fiber tension in glioblastoma for the first time ...
Michele Crestani, Isabel Gerber, Arnaud Mieville, Katrin Frauenknecht, Theoni Maragkou, Tibor Hortobagyi, Viola Vogel   +6 more
wiley   +1 more source

Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.

Journal of Clinical Investigation, 1993
D. Shweiki, A. Itin, G. Neufeld, H. Gitay-Goren, E. Keshet   +4 more
semanticscholar   +1 more source

Single‐Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients

Advanced Science, EarlyView.
scRNA sequencing reveals distinct tumor ecosystem features in CAYA‐PTC, marked by enriched CD4T_Tfh, CD8T_Tex cells, and rapid malignant thyrocyte differentiation (absent of mild‐state BRAF‐like population) toward invasive states. Prominent emCAF_LAMP5 populations interact with endothelial cells and thyrocytes facilitate angiogenesis and metastasis ...
Kai Guo, Lingyi Yang, Zirui Huang, Kai Qian, Yuan Shi, Mengjia Fei, Yuan Feng, Zixian Chen, Ming Qiu, Linglin Tang, Anqi Li, Zhibao Lv, Jiangbin Liu, Zhou Chen, Kuiran Dong, Zhuoying Wang   +15 more
wiley   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Soluble VEGFR‐2: an antilymphangiogenic variant of VEGF receptors

Annals of the New York Academy of Sciences, 2010
H. Pavlaković, J. Becker, R. Albuquerque, J. Wilting, J. Ambati   +4 more
semanticscholar   +1 more source

Guidance of Cell Migration by the Drosophila PDGF/VEGF Receptor [PDF]

, 2001
Peter Duchek, Kálmán Somogyi, Gáspár Jékely, Simone Beccari, Pernille Rørth   +4 more
openalex   +1 more source

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

Advanced Science, EarlyView.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser, Luz Jovita Dimas‐Harms, Rachel M. Lipman, Jake Inzalaco, Shaughn Bell, Michelle Alcantara, Erikha Valenzuela, George Lawless, Simion Kreimer, Sarah J. Parker, Helen S. Goodridge, Clive N. Svendsen   +11 more
wiley   +1 more source

Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish.

Proceedings of the National Academy of Sciences of the United States of America, 2006
Laurence D. Covassin, Jacques A Villefranc, Michael C. Kacergis, B. Weinstein, N. Lawson   +4 more
semanticscholar   +1 more source