Results 41 to 50 of about 2,468,898 (371)
Revising Berg-Purcell for finite receptor kinetics [PDF]
, 2021 From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv +1 more source
Respiratory Research, 2018 Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1α. The role of
Shaney L. Barratt +6 more
doaj +1 more source
Biological and Pharmaceutical Bulletin, 2011 Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) have crucial roles in both physiological and pathological angiogenesis. The VEGF family consists of VEGF-A (generally called VEGF), VEGF-B, VEGF-C, VEGF-D, and placental growth factor ...
Satoru Takahashi
semanticscholar +1 more source
Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?
Cancer Biology & Medicine, 2016 Vascular endothelial growth factor (VEGF) is primarily known as a proangiogenic factor and is one of the most important growth and survival factors affecting the vascular endothelium.
Yu-Ling Li, Hua Zhao, Xiu-Bao Ren
doaj +1 more source
Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]
EMBO J 22, 18 (15/09/2003) 4656-65, 2007 Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv +1 more source
β-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (VEGF) Receptors
Journal of Biological Chemistry, 2011 VEGF receptors have been the target of intense research aimed to develop molecules able to inhibit or stimulate angiogenesis. Based on the x-ray structure of the complex placental growth factor-VEGF receptor 1D2, we designed a VEGF receptor-binding ...
D. Diana +9 more
semanticscholar +1 more source
Computational model of vascular endothelial growth factor spatial distribution in muscle and pro-angiogenic cell therapy. [PDF]
PLoS Computational Biology, 2006 Members of the vascular endothelial growth factor (VEGF) family of proteins are critical regulators of angiogenesis. VEGF concentration gradients are important for activation and chemotactic guidance of capillary sprouting, but measurement of these ...
Feilim Mac Gabhann +2 more
doaj +1 more source
Frontiers in Pediatrics, 2021 Retinopathy of prematurity (ROP) is a leading cause of blindness in children worldwide. Blindness can occur from retinal detachment caused by pathologic retinal angiogenesis into the vitreous, termed intravitreal neovascularization (IVNV).
Aniket Ramshekar, M. Elizabeth Hartnett
doaj +1 more source
Tip cell overtaking occurs as a side effect of sprouting in computational models of angiogenesis [PDF]
BMC Systems Biology 2015, 9:86, 2015 During angiogenesis, endothelial cells compete for the tip position during angiogenesis: a phenomenon named tip cell overtaking. It is still unclear to what extent tip cell overtaking is a side effect of sprouting or to what extent a biological function.
arxiv +1 more source
Clinical Cancer Research, 2011 Purpose: Dovitinib (TKI258) is an orally available inhibitor of fibroblast growth factor (FGF), VEGF, and platelet-derived growth factor receptors.
Kevin B. Kim +5 more
semanticscholar +1 more source