Respiratory Research, 2018 Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1α. The role of
Shaney L. Barratt +6 more
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A multiscale hybrid model for pro-angiogenic calcium signals in a vascular endothelial cell [PDF]
, 2012 Cytosolic calcium machinery is one of the principal signaling mechanisms by which endothelial cells (ECs) respond to external stimuli during several biological processes, including vascular progression in both physiological and pathological conditions ...
A. Balter +102 more
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Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?
Cancer Biology & Medicine, 2016 Vascular endothelial growth factor (VEGF) is primarily known as a proangiogenic factor and is one of the most important growth and survival factors affecting the vascular endothelium.
Yu-Ling Li, Hua Zhao, Xiu-Bao Ren
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VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain [PDF]
, 2015 © 2015. Published by The Company of Biologists Ltd. This research was funded by a Wellcome Trust PhD fellowship to M.T. [092839/Z/10/Z] and a BBSRC project grant to C.R. and L.E. [BB/J00930X/1].
Cariboni, Anna +6 more
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Regulation of vascular endothelial growth factor bioactivity in patients with acute lung injury [PDF]
, 2005 Background: Reduced bioactive vascular endothelial growth factor (VEGF) has been demonstrated in several inflammatory lung conditions including the acute respiratory distress syndrome (ARDS).
Armstrong, L. +6 more
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β-Hairpin Peptide That Targets Vascular Endothelial Growth Factor (VEGF) Receptors
Journal of Biological Chemistry, 2011 VEGF receptors have been the target of intense research aimed to develop molecules able to inhibit or stimulate angiogenesis. Based on the x-ray structure of the complex placental growth factor-VEGF receptor 1D2, we designed a VEGF receptor-binding ...
D. Diana +9 more
semanticscholar +1 more source
Hepatocellular carcinoma and multidrug resistance: Past, present and new challenges for therapy improvement [PDF]
, 2015 Hepatocellular carcinoma (HCC) is the most common malignancy of the liver and the third cause of cancer death worldwide. Chronic hepatitis due to HBV and HCV infection are two major risk factors for HCC worldwide.
Cuestas, María Luján +2 more
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The role of VEGF receptors in angiogenesis; complex partnerships
Cellular and Molecular Life Sciences, 2006 .Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development and homeostasis but also have profound effects on neural cells.
Stéphanie Cébe-Suarez +2 more
semanticscholar +1 more source
Journal of Orthopaedic Surgery and Research, 2009 Background Apoptosis of osteoblasts and osteoclasts regulates bone homeostasis. Skeletal injury in humans results in 'angiogenic' responses primarily mediated by vascular endothelial growth factor(VEGF), a protein essential for bone repair in animal ...
Street John, Lenehan Brian
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Computational model of vascular endothelial growth factor spatial distribution in muscle and pro-angiogenic cell therapy. [PDF]
PLoS Computational Biology, 2006 Members of the vascular endothelial growth factor (VEGF) family of proteins are critical regulators of angiogenesis. VEGF concentration gradients are important for activation and chemotactic guidance of capillary sprouting, but measurement of these ...
Feilim Mac Gabhann +2 more
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