Results 51 to 60 of about 2,468,898 (371)
Prolonged blockade of VEGF receptors does not damage retinal photoreceptors or ganglion cells
Journal of Cellular Physiology, 2010 It has recently been reported that relatively short‐term inhibition of vascular endothelial growth factor (VEGF) signaling can cause photoreceptor cell death, a potentially clinically important finding since VEGF blockade has become an important modality
A. Miki +9 more
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Journal of Orthopaedic Surgery and Research, 2009 Background Apoptosis of osteoblasts and osteoclasts regulates bone homeostasis. Skeletal injury in humans results in 'angiogenic' responses primarily mediated by vascular endothelial growth factor(VEGF), a protein essential for bone repair in animal ...
Street John, Lenehan Brian
doaj +1 more source
Current Issues in Molecular Biology, 2022 Vascular endothelial growth factors (VEGFs) are important regulators of angiogenesis, neuroprotection, and neurogenesis. Studies have indicated the association of VEGF dysregulation with the development of neurodegenerative and cerebrovascular diseases ...
Anastasiya S. Babkina +7 more
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Journal of Clinical Investigation, 1993 Vascular endothelial growth factor (VEGF) is a secreted endothelial cell-specific mitogen. To evaluate whether VEGF may play a role in angiogenesis, we have determined the spatial and temporal patterns of expression of VEGF and VEGF receptors during ...
D. Shweiki +4 more
semanticscholar +1 more source
Computational Modeling of Interacting VEGF and Soluble VEGF Receptor Concentration Gradients [PDF]
Frontiers in Physiology, 2011 Experimental data indicates that soluble vascular endothelial growth factor (VEGF) receptor 1 (sFlt-1) modulates the guidance cues provided to sprouting blood vessels by VEGF-A. To better delineate the role of sFlt-1 in VEGF signaling, we have developed an experimentally based computational model. This model describes dynamic spatial transport of VEGF,
Yasmin L Hashambhoy +9 more
openaire +4 more sources
Сибирский онкологический журнал, 2021 Purpose: to study the expression of vascular endothelial growth factor (vegf-a) and its receptors (vegfr-1 and vegfr-2) in renal cell carcinoma (rcc) cells and assess the effect of the expression levels of these markers on the tumor characteristics and ...
D. A. Khochenkov +7 more
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Large number of receptors may reduce cellular response time variation [PDF]
Physical biology 10 (3), 035008, 2013, 2012 Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv +1 more source
Gene Expression Analysis of VEGF and Its Receptors and Assessment of Its Serum Level in Unexplained Recurrent Spontaneous Abortion [PDF]
Cell Journal, 2015 Objective: Unexplained recurrent spontaneous abortion (URSA) is one of the main complications of pregnancy which is usually defined as three or more consecutive pregnancy losses before the 20th week of gestation without a known cause.
Elham Amirchaghmaghi +5 more
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A Hybrid Model of the Role of VEGF Binding in Endothelial CellMigration and Capillary Formation
Frontiers in Oncology, 2013 Vascular endothelial growth factor (VEGF) is the most studied family of soluble secreted mediators of endothelial cell migration, survival and proliferation.
Harsh eJain, Trachette eJackson
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Biomolecules, 2020 Vascular endothelial growth factors (VEGFs) bind to membrane receptors on a wide variety of cells to regulate diverse biological responses. The VEGF-A family member promotes vasculogenesis and angiogenesis, processes which are essential for vascular ...
Faheem Shaik +5 more
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