Results 51 to 60 of about 2,633,569 (375)

Gene Expression Analysis of VEGF and Its Receptors and Assessment of Its Serum Level in Unexplained Recurrent Spontaneous Abortion [PDF]

Cell Journal, 2015
Objective: Unexplained recurrent spontaneous abortion (URSA) is one of the main complications of pregnancy which is usually defined as three or more consecutive pregnancy losses before the 20th week of gestation without a known cause.
Elham Amirchaghmaghi, Abbas Rezaei, Ashraf Moini, Mohammad Ali Roghaei, Maryam Hafezi, Reza Aflatoonian   +5 more
doaj  

A Hybrid Model of the Role of VEGF Binding in Endothelial CellMigration and Capillary Formation

Frontiers in Oncology, 2013
Vascular endothelial growth factor (VEGF) is the most studied family of soluble secreted mediators of endothelial cell migration, survival and proliferation.
Harsh eJain, Trachette eJackson
doaj   +1 more source

Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy

Biomolecules, 2020
Vascular endothelial growth factors (VEGFs) bind to membrane receptors on a wide variety of cells to regulate diverse biological responses. The VEGF-A family member promotes vasculogenesis and angiogenesis, processes which are essential for vascular ...
Faheem Shaik, Gary A. Cuthbert, Shervanthi Homer-Vanniasinkam, Stephen P. Muench, Sreenivasan Ponnambalam, Michael A. Harrison   +5 more
doaj   +1 more source

The role of VEGF receptors in angiogenesis; complex partnerships

Cellular and Molecular Life Sciences, 2006
.Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel development and homeostasis but also have profound effects on neural cells.
Stéphanie Cébe-Suarez, A. H. M. Zehnder-Fjällman, K. Ballmer-Hofer   +2 more
semanticscholar   +1 more source

Mutated TP53 is a marker of increased VEGF expression: analysis of 7,525 pan-cancer tissues. [PDF]

, 2020
Anti-angiogenic therapies are an important class of anti-cancer treatment drugs. However, their efficacy is limited to certain tumors and would benefit from identifying a biomarker predictive of therapeutic response.
Boichard, Amélie, Kurzrock, Razelle, Li, Alex M   +2 more
core  

Inhibition of Melanoma Angiogenesis by Telomere Homolog Oligonucleotides [PDF]

, 2010
Telomere homolog oligonucleotides (T-oligos) activate an innate telomere-based program that leads to multiple anticancer effects. T-oligos act at telomeres to initiate signaling through the Werner protein and ATM kinase.
Coleman, Christina, Gilchrest, Barbara A., Goukassian, David A., Kishore, Raj, Lambers, Erin, Levine, Danielle, Qin, Gangjian, Sasi, Sharath P., Thorne, Tina, Yaar, Mina   +9 more
core   +5 more sources

Engineered microenvironments for synergistic VEGF - integrin signalling during vascularization [PDF]

, 2017
We have engineered polymer-based microenvironments that promote vasculogenesis both in vitro and in vivo through synergistic integrin-growth factor receptor signalling. Poly(ethyl acrylate) (PEA) triggers spontaneous organization of fibronectin (FN) into
Cantini, Marco, Costell, Mercedes, Dalby, Matthew J., García, Andrés J., Gonzalez-Garcia, Cristina, Moulisová, Vladimíra, Rodrigo-Navarro, Aleixandre, Sabater i Serra, Roser, Salmerón-Sánchez, Manuel, Weaver, Jessica   +9 more
core   +2 more sources

Compartment model predicts VEGF secretion and investigates the effects of VEGF Trap in tumor-bearing mice

Frontiers in Oncology, 2013
Angiogenesis, the formation of new blood vessels from existing vasculature, is important in tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth factor (VEGF), which has been targeted in numerous anti-angiogenic ...
Stacey D Finley, Manjima eDhar, Aleksander S. Popel   +2 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A Mathematical Model for Lymphangiogenesis in Normal and Diabetic Wounds

, 2015
Several studies suggest that one possible cause of impaired wound healing is failed or insufficient lymphangiogenesis, that is the formation of new lymphatic capillaries.
Bianchi, Arianna, Painter, Kevin J., Sherratt, Jonathan A.   +2 more
core   +1 more source