Results 51 to 60 of about 3,575,601 (344)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Assessment of Vehicle Volatility and Deposition Layer Thickness in Skin Penetration Models
Pharmaceutics, 2021 Systemic disposition of dermally applied chemicals is often formulation-dependent. Rapid evaporation of the vehicle can result in crystallization of active compounds, limiting their degree of skin penetration.
Abdullah Hamadeh +2 more
doaj +1 more source
Coupling device for moving vehicles [PDF]
, 1979 A mechanical system is disclosed to capture and/or deploy a device or vehicle having relative motion with respect to another vehicle. The mechanism includes an onboard controlled collapsible iris assembly located at the end of a controlled manipulator ...
Rudmann, A. A.
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Driving a vehicle without a driving licence in the New Romanian Criminal Code
Journal of Legal Studies, 2016 Improving the traffic safety represents a central objective of the European Union’s policy in the transports field. The Union has in view an improvement of the traffic safety, having as purpose the diminishing of deaths, bodily injuries and material ...
Zazula Bela
doaj +1 more source
A New Faulty GNSS Measurement Detection and Exclusion Algorithm for Urban Vehicle Positioning
Remote Sensing, 2021 The performance requirements for Global Navigation Satellite Systems (GNSS) are becoming more demanding as the range of mission-critical vehicular applications, including the Unmanned Aerial Vehicle (UAV) and ground vehicle-based applications, increases.
Qi Cheng +5 more
doaj +1 more source
The application of combined momentum and blade element theory for aerodynamics performance analysis of rotating blades [PDF]
, 2011 In this thesis, a simulation package for the Six Degrees of Freedom (6DOF ) motion of an underwater vehicle is developed. Mathematical modeling of an underwater vehicle is done and the parameters needed to write such a simulation package are ...
M Mohammed, Abdelrazzak Gumaa
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Development of Water-Insoluble Vehicle Comprising Natural Cyclodextrin—Vitamin E Complex
Antioxidants, 2021 Development of a novel antioxidant-delivery vehicle exerting biosafety has been attracting a great deal of interest. In this study, a vehicle comprising a natural composite consisting of vitamin E (α-tocopherol; Toc) and cyclodextrin (CD) additives was ...
Shigesaburo Ogawa +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source