Results 261 to 270 of about 32,663,247 (352)

PlatROB: An open-source, modular, and low-cost hardware platform for mobile robotics and AI education. [PDF]

HardwareX
Balbuena J, Sinche J, Quiroz D, Arce D, Villota E.   +4 more
europepmc   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

In vivo base editing rescues ADPKD in a humanized mouse model. [PDF]

Nat Commun
Cheng AS, Li LX, Zhou JX, Harris PC, Calvet JP, Li X.   +5 more
europepmc   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

HyAR-PPO: Hybrid Action Representation Learning for Incentive-Driven Task Offloading in Vehicular Edge Computing. [PDF]

Sensors (Basel)
Wang W, Li M, Wu H.
europepmc   +1 more source

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Protocol for ex vivo mouse paired single-gonad screening platform for phenotypical characterization. [PDF]

STAR Protoc
Estermann MA, Rodriguez KF, Hunnicutt J, Yao HH.   +3 more
europepmc   +1 more source

Therapeutic potential of synergistic mucociliary clearance for cystic fibrosis airways by β-adrenergic plus cholinergic agonists. [PDF]

J Clin Invest
Joo NS, Birket SE, Keith JD, Ianowski JP, Luan X, Spano J, Bollyky JB, Dobry MN, Sabater JR, Williams RW, Engelhardt JF, Wine JJ, Milla CE.   +12 more
europepmc   +1 more source

Ultrasonic Evaluation of the Adhesion Between Regenerative Coatings and Steel Substrates. [PDF]

Materials (Basel)
Kowalczyk J, Jósko M, Matysiak W.
europepmc   +1 more source

Dynamic chain for scheduling of the multi-AGV systems with load-aware motion profiling. [PDF]

Sci Rep
Nguyen TP, Nguyen H, Phan DM, Ngo HQT.
europepmc   +1 more source