Results 31 to 40 of about 509,429 (267)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Research on LPV-H∞ control strategy of magnetorheological semi-active suspension with air spring

Scientific Reports
In order to improve the ride comfort and safety of the vehicle, a linear parameter varying H∞ control of magnetorheological semi-active air suspension was proposed to solve a series of problems caused by parameter changes and external disturbances. Based
Gang Li, Shaohua Zhang, Jiantao Li, Qingsheng Huang, Qianjie liu, Lin Zhong, Wenjun Sun, Ruqi Ding, Guoliang Hu, Jianming Deng   +9 more
doaj   +1 more source

Framework for Vehicle Dynamics Model Validation

IEEE Access, 2022
Vehicle dynamics models are widely used in many areas of the automotive industry. The usability of each model depends on how well it is able to mimic the behavior of the real vehicle. Each simulation model must go through a thorough investigation process
Attila Widner, Viktor Tihanyi, Tamas Tettamanti   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Exact particle flow Daum-Huang filters for mobile robot localization in occupancy grid maps

Complex & Intelligent Systems
In this paper, we present a novel localization algorithm for mobile robots navigating in complex planar environments, a critical capability for various real-world applications such as autonomous driving, robotic assistance, and industrial automation ...
Domonkos Csuzdi, Tamás Bécsi, Péter Gáspár, Olivér Törő   +3 more
doaj   +1 more source

Residual Reinforcement Learning Enhanced With Unsuccessful Episode Buffer

IEEE Open Journal of the Computer Society
Reinforcement learning (RL) agents have proven to be highly effective in many control domains; however, despite their generally promising performance, they may still encounter difficulties in certain challenging scenarios.To address this limitation, we ...
Peter Farkas, Tamas Becsi, Szilard Aradi
doaj   +1 more source

Modeling of occupant behavior under lateral vehicle motion (Proposing of control laws based on human posture control mechanism and experimental validation)

Nihon Kikai Gakkai ronbunshu, 2022
To achieve simple and accurate modeling of human-like behavior with the aim of realizing a model-based design (MBD) methodology incorporating vehicle occupants, this research applied a simplified two-mass system for the upper body of a vehicle occupant ...
Tetsu YASUI, Hideki SUGIURA, Eiichi ONO
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

MCTS-Based Policy Improvement for Reinforcement Learning

Machine Learning and Knowledge Extraction
Curriculum Learning (CL) is a potent field in Machine Learning that provides several excellent techniques for enhancing the performance of the training process given the same data points, regardless of the training method used.
György Csippán, István Péter, Bálint Kővári, Tamás Bécsi   +3 more
doaj   +1 more source