Results 41 to 50 of about 1,977,325 (303)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Simple and high‐performance cell balancing control strategy

Energy Science & Engineering, 2022
The basis for judging whether the battery pack is balanced is generally whether the voltage of the battery cell is consistent because the voltage of the battery cell is very easy to obtain.
Zilong Chen, Wenjun Liao, Pingfei Li, Jinhui Tan, Yuping Chen   +4 more
doaj   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Research on LPV-H∞ control strategy of magnetorheological semi-active suspension with air spring

Scientific Reports
In order to improve the ride comfort and safety of the vehicle, a linear parameter varying H∞ control of magnetorheological semi-active air suspension was proposed to solve a series of problems caused by parameter changes and external disturbances. Based
Gang Li, Shaohua Zhang, Jiantao Li, Qingsheng Huang, Qianjie liu, Lin Zhong, Wenjun Sun, Ruqi Ding, Guoliang Hu, Jianming Deng   +9 more
doaj   +1 more source

Framework for Vehicle Dynamics Model Validation

IEEE Access, 2022
Vehicle dynamics models are widely used in many areas of the automotive industry. The usability of each model depends on how well it is able to mimic the behavior of the real vehicle. Each simulation model must go through a thorough investigation process
Attila Widner, Viktor Tihanyi, Tamas Tettamanti   +2 more
doaj   +1 more source

GPS-guided mobile robot platform featuring modular design elements for agricultural applications : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Engineering in Mechatronics at Massey University Turitea Campus, Palmerston North, New Zealand [PDF]

, 2016
The agricultural industry has not seen significant innovation in development of low-cost automated farming solutions, with current systems costing several thousands of dollars to implement.
Corpe, Samuel John Oldfield
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Exact particle flow Daum-Huang filters for mobile robot localization in occupancy grid maps

Complex & Intelligent Systems
In this paper, we present a novel localization algorithm for mobile robots navigating in complex planar environments, a critical capability for various real-world applications such as autonomous driving, robotic assistance, and industrial automation ...
Domonkos Csuzdi, Tamás Bécsi, Péter Gáspár, Olivér Törő   +3 more
doaj   +1 more source

Residual Reinforcement Learning Enhanced With Unsuccessful Episode Buffer

IEEE Open Journal of the Computer Society
Reinforcement learning (RL) agents have proven to be highly effective in many control domains; however, despite their generally promising performance, they may still encounter difficulties in certain challenging scenarios.To address this limitation, we ...
Peter Farkas, Tamas Becsi, Szilard Aradi
doaj   +1 more source