Results 61 to 70 of about 1,977,325 (303)
Overlooked crisis: cold temperature amplifies particle number emissions from gasoline vehicles
Environment InternationalThis study systematically investigates particle number (PN) emissions from light-duty gasoline vehicles through chassis dynamometer (60 emission test runs spanning −7 °C to 40 °C) combined with mechanistic analysis, revealing a severely underestimated ...
Xihui Tong +11 more
doaj +1 more source
LPV-Based Controller Design of a Floating Piston Pneumatic Actuator
Actuators, 2020 The paper presents the modeling and control design of a floating piston pneumatic gearbox actuator using a grid-based Linear Parameter Varying approach. First, the nonlinear model of the pneumatic actuator is presented, then it is transformed into a 6th ...
Ádám Szabó +3 more
doaj +1 more source
A Vectoring Thrust Coaxial Rotor for Micro Air Vehicle: Modeling, Design and Analysis [PDF]
, 2013 The growing interest of rotary wing UAVs, for military and civilian applications, has encouraged designers to consider miniaturized configurations, more efficient in terms of endurance, payload capability and maneuverability. The purpose of this paper is
Moschetta, Jean-Marc, Prothin, Sebastien
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
AIP Advances, 2020 An implicit large-eddy simulation method is used to numerically simulate the flowfield around a finite-span rectangular wing in pitch motion. The effect of the reduced frequency (k) on the stability of the leading-edge vortex (LEV) is studied.
JiaoLong Zhang +3 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Guided Experience Prioritization for Continuous Reinforcement Learning
IEEE AccessA primary limiting factor in modern deep learning is the availability of computational resources, a constraint that becomes particularly pronounced in the context of complex reinforcement learning tasks.
Istvan Gellert Knab +2 more
doaj +1 more source
Body Travel Performance Improvement of Space Vehicle Electromagnetic Suspension System using LQG and LQI Control Methods [PDF]
, 2020 Electromagnetic suspension system (EMS) is mostly used in the field of high-speed vehicle. In this paper, a space exploring vehicle quarter electromagnetic suspension system is modelled, designed and simulated using linear quadratic optimal control ...
Jibril, Mustefa
core
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source