Advanced Science, EarlyView.ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen +7 more
wiley +1 more source
A Curriculum Approach to Reduce the Dynamics-Related Reality Gap in Autonomous Driving Decision-Making. [PDF]
Sensors (Basel)Gutiérrez-Moreno R +5 more
europepmc +1 more source
VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
Stability control of suspended monorail vehicles based on PID and quadratic programming allocation. [PDF]
Sci RepJiang Y, Wang D, Chen R, Wang Q, Du Z.
europepmc +1 more source
Chiral Morphing of Liquid Crystal Polymer Networks
Advanced Science, EarlyView.This paper reviews how macroscopic chirality spontaneously arises from liquid crystal polymer materials. It describes how alignment is utilized to create the mechanical anisotropy, geometric misorientation and asymmetry that leads to chiral shape morphing, how shape selection between helicoids and helices arises, the techniques used to prepare these ...
Laurens T. de Haan
wiley +1 more source
Active Fault-Tolerant Control for Steering Actuator Bias in Autonomous Vehicles Using Adaptive Sliding Mode Observer. [PDF]
Sensors (Basel)Kim H, Kim W.
europepmc +1 more source
Advanced Science, EarlyView.We elucidate the electrochemical actuation mechanism of 2D material‐based electrodes within a MXene‐centered framework, linking atomic‐scale surface chemistry to macroscopic performance (see schematic). Mechanistically, the reduction of Ti─O─Ti sites in H2SO4 triggers the accumulation of hydrated ions at confined active sites, resulting in anomalous ...
Jiang Xu +6 more
wiley +1 more source
Unsupervised Driving Behavior Primitive Inference via Hierarchical Segmentation and Context-Aware Clustering. [PDF]
Sensors (Basel)Zhang L, Li T, Zheng X, Kang W, Fu Y.
europepmc +1 more source
Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders
Advanced Science, EarlyView.Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley +1 more source
Learning-aided observer design for improving autonomous vehicle safety. [PDF]
Sci RepMihály A +4 more
europepmc +1 more source