Results 131 to 140 of about 26,385 (312)
Dataset for the cumulative unmanned aerial vehicle routing problem. [PDF]
Data Brief, 2023 Kyriakakis NA +3 more
europepmc +1 more source
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis
Advanced Science, EarlyView.Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang +16 more
wiley +1 more source
An innovative medical waste management system in a smart city using XAI and vehicle routing optimization. [PDF]
F1000Res, 2023 Boudanga Z, Benhadou S, Medromi H.
europepmc +1 more source
Heuristic and exact methods applied to a rich vehicle routing and scheduling problem. [PDF]
, 2013 Michel Povlovitsch Seixas
openalex +1 more source
Promece - Routing Optimization - Vehicle Routing Optimization
, 2015 PROMECE 2015. Project funded by the Valencian Institute of Business Competitiveness (IVACE) and the European Union through the European Regional Development Fund (ERDF), within the public grant program adressed to Technological Institutes of IVACE network.
openaire +1 more source
Advanced Science, EarlyView.Acute brain injuries are characterized by extensive tissue damage, resulting in debilitating deficits in patients. Despite considerable progress, cell‐based approaches have yet to identify an ideal candidate. This long‐term study explores the use of an untested cell source – human enteric glia – and a non‐invasive administration route – intranasal ...
Nina Colitti +11 more
wiley +1 more source
Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors
Advanced Science, EarlyView.Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon +10 more
wiley +1 more source
Benchmarking a fast, satisficing vehicle routing algorithm for public health emergency planning and response: "Good Enough for Jazz". [PDF]
PeerJ Comput Sci, 2023 McDaniel EL +3 more
europepmc +1 more source
Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages
Advanced Science, EarlyView.Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu +14 more
wiley +1 more source