Results 201 to 210 of about 162,259 (267)

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Research on active collision avoidance control technology for intelligent connected monorail transit trains in the virtual coupling environment. [PDF]

PLoS One
Hou Z, Liang H, Yang G, Han J.
europepmc   +1 more source

REGγ Suppresses Ferroptosis and Induces Drug Resistance by Degrading WDR6 in Chondrosarcoma

Advanced Science, EarlyView.
Here, we identified REGγ as a susceptibility factor in chondrosarcoma. Our study demonstrates that abnormally activated REGγ‐20S proteasome promotes chondrosarcoma development and progression. Further validation in animal models revealed that blocking REGγ function induced ferroptosis, suppressed malignant progression of chondrosarcoma, and uncovered a
Fanrong Liu, Shihui Shen, Dongxia Li, Peilin Shi, Jiaming Xu, Tongxin Lv, Yingying Du, Jingwei Zhang, Bo Yang, Hansen Chen, Zhuoya Peng, Wenjie Ren, Lu Zhang, Sheng Cheng, Tongjin Yin, Wencai Sheng, Lei Li, Juan Wu, Qingcheng Yang, Shuogui Xu, Wei Zheng   +20 more
wiley   +1 more source

Crisaborole 2% for Pediatric Periorificial Dermatitis: A Randomized, Double-Blind, Vehicle-Controlled Pilot Study. [PDF]

Ann Dermatol
Ollech A, Aluma BB, Weiss-Fink A, Horev A, Toker O, Czarnowicki T.   +5 more
europepmc   +1 more source

ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief

Advanced Science, EarlyView.
ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng, Changyu Liu, Qin Xia, Arndt F. Schilling, Jiawei Jiang, Renpeng Peng, Zixing Shu, Tian Ma, Danni Luo, Yaoyu Zhang, Yibo Fan, Xuyuan Zhang, Song Li, Kai Wang, Wentao Ke, Yuan Xiong, Yuanli Zhu, Fangzhi Mou, Jun Xiao, Hao Zhu   +19 more
wiley   +1 more source

Comfort-Oriented Pothole Traversal Using Multi-Sensor Perception and Fuzzy Control. [PDF]

Sensors (Basel)
Yuan C, Hang S, He Y, Shen J, Chen L, Cai Y, Weng S, Wang J.   +7 more
europepmc   +1 more source

Visual Impairment and Driving in Older Adults: A Narrative Review. [PDF]

Curr Treat Options Neurol
Xu S, Ehrlich JR, De Lott LB.
europepmc   +1 more source

Reproxalap - A Novel Treatment Option for Allergic Conjunctivitis - A Comprehensive Narrative Review. [PDF]

Health Sci Rep
Mughal S, Awan RE, Abbas H, Sania Z, Habib A, Sakina SK, Mahmud A, Eljack MMF.   +7 more
europepmc   +1 more source

Study on the optimization of natural gas station inspection paths considering station priority. [PDF]

Sci Rep
Peng X, Li J, Yuan Y.
europepmc   +1 more source

Therapeutic Efficacy and Safety of Recombinant Botulinum Toxin Type A for Moderate to Severe Glabellar Lines: A Randomized, Controlled, Double-blind, Phase III Trial in Chinese Adults. [PDF]

Aesthet Surg J
Wu Y, Long X, Yu N, Chen J, Lu J, Tan L, Lai W, Li L, Wu S, Wu L, Sun J, Bi H, Geng S, Wang H, Luo S, Hu Z, Yang J, Wang B, Yang W, Sun X, Sun X.   +20 more
europepmc   +1 more source