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mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

open access: yesAdvanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim   +4 more
wiley   +1 more source
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The Vehicle Scheduling Problem with Multiple Vehicle Types

Journal of the Operational Research Society, 1988
The paper is concerned with a special scheduling problem: for given start locations, end locations and start time intervals find a feasible schedule with minimal operating costs. The problem formulation is extended to the case of multiple vehicle types.
Jacques A Ferland, Philippe Michelon
exaly   +2 more sources

A Polyhedral Approach to Simplified Crew Scheduling and Vehicle Scheduling Problems

Management Science, 2001
Crew and vehicle scheduling are fundamental issues in public transit management. Informally, they can be described as the problem of determining the optimal duties for a set of crews (e.g., bus drivers) or vehicles (e.g., buses) so as to cover a given set of timetabled trips, satisfying a number of constraints laid down by the union contract and ...
Matteo Fischetti   +2 more
exaly   +4 more sources

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