Results 51 to 60 of about 20,429 (312)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Analysis of Multi-Path Scheduling Network Model for Intelligent Transportation
Dianxin kexue, 2014 In the field of intelligent transportation, vehicle scheduling is a complex issue with multi-path, multi-types of vehicles and multi-destination. In this process, some time-varying attributes and dynamic indicators have a direct impact on the scheduling ...
Weiyang Qin
doaj +2 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Risk Coupling Assessment of Vehicle Scheduling for Shipyard in a Complicated Road Environment
Journal of Marine Science and EngineeringVehicle scheduling at shipyards can involve delays due to numerous risk factors encountered in the complicated shipyard road environment. This paper studies the problems of risk coupling in shipyard vehicle scheduling based on the risk matrix approach ...
Ningfei Wang +2 more
doaj +1 more source
A Cluster-based Optimal Scheduling Strategy for Electric Vehicles Considering User Participation
Kongzhi Yu Xinxi Jishu, 2021 To solve the scheduling problem of large-scale electric vehicles participating in peak shaving, this paper presents a cluster-based optimal scheduling strategy for electric vehicles considering user participation.
HAN Yan +3 more
doaj
PLoS ONE, 2021 Coordinating the charging scheduling of electric vehicles for dynamic dial-a-ride services is challenging considering charging queuing delays and stochastic customer demand.
Tai-Yu Ma
doaj +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Fuzzy Evolutionary Approaches for Bus and Rail Driver Scheduling [PDF]
, 2002 Bus and train driver scheduling is a process of partitioning blocks of work, each of which is serviced by one vehicle, into a set of legal driver shifts.
Li, Jingpeng
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
An optimized two‐phase demand‐responsive transit scheduling model considering dynamic demand
IET Intelligent Transport SystemsDemand‐responsive transit has gradually attracted attention in recent years for its flexibility, efficiency, and ability to meet the diverse travel demands of passengers.
Cui‐Ying Song +3 more
doaj +1 more source