Results 231 to 240 of about 636,815 (304)

City-scale high-resolution traffic datasets with refined networks for hierarchical traffic control. [PDF]

Sci Data
Ma Q, Guo X, Zhong W, He Z, Su Z, Ma W, Zhong R.   +6 more
europepmc   +1 more source

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Multi-parameter and multi-objective collaborative optimization of a suspended monorail vehicle addressing its strongly coupled nonlinear characteristics. [PDF]

Sci Rep
Jiang Y, Zhang S, Liu W, Chen R, Wang Q.
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Investigating the impact of electric vehicles on increasing the reliability of the distribution system using the enhanced gray wolf evolutionary algorithm model. [PDF]

Sci Rep
Naeimi M, Samiei Moghaddam M, Azarfar A, Vahedi M, Koochaksaraei JS.   +4 more
europepmc   +1 more source

Causal Prediction of TP53 Variant Pathogenicity Using a Perturbation‐Informed Protein Language Model

Advanced Science, EarlyView.
A TP53‐specific predictor, CaVepP53, is developed by fine‐tuning ESMC on experimentally validated variants, quantifying pathogenicity via Euclidean distances. It outperforms general‐purpose models and extends to five cancer genes, enabling interpretable variant classification for precision medicine.
Huiying Chen, Yang Zhao, Boqiang Hu, Wuke Wang, Minfang Song, Annabeth Xinyu Zhao, Xiangyang Li, Gefei Wang, Yanfen Wang, Weiyan Zheng, Xinpeng Zhang, Xia Lin, Yanbin Yin, Xingxu Huang, Jinfang Zheng, Tingbo Liang   +15 more
wiley   +1 more source

Decentralized electric vehicle charging enables large-scale photovoltaic integration in tropical cities. [PDF]

Nat Commun
Zhou J, Dong T, Yang H, Yean S, Lee BS, Schläpfer M.   +5 more
europepmc   +1 more source

A simulation model to predict agricultural tractor-semi-trailer combination traction performance under different operating conditions. [PDF]

Sci Rep
Fouda T, Hegazy R, Alhamshary K.
europepmc   +1 more source

Dataset for multi-perspective traffic video analysis. [PDF]

Sci Data
Sanchez-Iborra R, Kouvakis V, Trevlakis SE, Alarcon-Hellin G, Tsiftsis T, Bernal-Escobedo L, Asensio-Garriga R, Boulogeorgos AA, Skarmeta A.   +8 more
europepmc   +1 more source

Trajectory Prediction-Enabled Self-Decision-Making for Autonomous Cleaning Robots in Semi-Structured Dynamic Campus Environments. [PDF]

Sensors (Basel)
Peng J, Zhu Z, Fan Q, Xia R, Yin Z.
europepmc   +1 more source