Results 41 to 50 of about 1,303,176 (294)
Chinese Journal of Mechanical Engineering, 2021 The tribological properties of cylinder block/valve plate is an important consideration in the design of axial piston pump. The effect of materials and heat treatment on friction and wear properties has been studied in depth. Engineering experiences show
Jiahai Huang +4 more
doaj +1 more source
A State-of-Charge Estimation Method Based on Multi-Algorithm Fusion
World Electric Vehicle Journal, 2022 Lithium-ion power batteries are widely used in the electric vehicle (EV) industry due to their high working voltage, high energy density, long cycle life, low self-discharge rate, and environmental protection.
Aihua Tang +5 more
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SOBER ASSESSMENT OF ECONOMIC FEASIBILITY OF RENEWABLE ENERGY AND VEHICLE-TO-GRID TECHNOLOGIES IN UKRAINE [PDF]
, 2018 Estimate economical rationale of vehicle-to-grid technology (V2G) in Ukraine in with and without renewable energy ...
BALAKHONTSEV, Alexander +9 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Influence of printing direction on 3D printed ABS specimens
Production Engineering Archives, 2020 In the recent years, additive manufacturing became an interesting topic in many fields due to the ease of manufacturing complex objects. However, it is impossible to determine the mechanical properties of any additive manufacturing parts without testing ...
Markiz Nassim +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
, 2018 By using the onboard sensing and external connectivity technology, connected and automated vehicles (CAV) could lead to improved energy efficiency, better routing, and lower traffic congestion.
Chang, Yan, Yang, Weiqing, Zhao, Ding
core +1 more source