Results 61 to 70 of about 346,921 (314)

The impact of hybrid and electric powertrains on vehicle dynamics, control systems and energy regeneration [PDF]

, 2012
The background to the development of so-called green or low-carbon vehicles continues to be relentlessly reviewed throughout the literature. Research and development (R&D) on novel powertrains – often based on electric or hybrid technology – has been ...
Cao, Dongpu, Crolla, David
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Vehicle fuel efficiency standards [PDF]

, 2013
This paper provides an overview of mandatory vehicle CO2 emission (mandatory fuel efficiency) standards adopted overseas and the standards adopted by Australia.IntroductionFuel efficiency pertains to the conversion of chemical fuel energy into vehicle ...
Matthew L. James
core  

Vehicle-bridge dynamic interaction using finite element modelling

, 2010
First investigations on the dynamic response of bridges due to moving loads were motivated by the collapse of the Chester railway bridge in the UK in the middle of the 19th century.
Arturo Gonzalez, González, Arturo
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Study of the Thermal Performance of Oil-Cooled Electric Motor with Different Oil-Jet Ring Configurations

Energies
This study investigates the thermal performance of an oil-jet-cooled permanent magnet synchronous motor (PMSM), with a particular focus on end-winding heat dissipation.
Hao Yang, Fan Wu, Jinhao Fu, Junxiong Zeng, Xiaojin Fu, Guangtao Zhai, Feng Zhang   +6 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Research on engine power-loss fault diagnosis method based on time-series data mining

Scientific Reports
Traditional diagnostic approaches for engine power-loss faults in commercial vehicles are limited by their heavy reliance on on-site road testing and high consumption of human and material resources.
Li Feng, Le Liu, Hongsheng Xu, Sumeng Gao, Hai Tang, Jianing Cui, Bin Zhang, Yufeng Rao   +7 more
doaj   +1 more source

Optimal Guidance Law for Critical Safe Miss Distance Evasion

Aerospace
In pursuit–evasion scenarios, the pursuer typically possesses a lethal zone. If the evader effectively utilizes perceptual information, they can narrowly escape the lethal zone while minimizing energy consumption, thereby avoiding excessive and ...
Chengze Wang, Jiamin Yan, Rui Lyu, Zhuo Liang, Yang Chen   +4 more
doaj   +1 more source