YIPFα1A expression is regulated by multilayered molecular mechanisms
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Manned Mars Explorer project: Guidelines for a manned mission to the vicinity of Mars using Phobos as a staging outpost; schematic vehicle designs considering chemical and nuclear electric propulsion [PDF]
The Manned Mars Explorer (MME) project responds to the fundamental problems of sending human beings to Mars in a mission scenario and schematic vehicle designs.
Baxmann, C. J., Neubek, Deb, Nolan, Sean
core +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
High Performance Low Temperature Methanol-Water Plasma Reforming
This research studied a high performance, low temperature reforming system with a power supply input of 12V/150W. A methanol-water mixture was used as fuel and atomized into particles with a diameter of 2∼3 µm through the use of a high ...
Bai-Fu LIN +3 more
doaj +1 more source
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Analysis on the key construction technology of steel structure in prefabricated high-rise building-A case study of Pingshan new energy vehicle industrial park in Shenzhen [PDF]
Bohan Gao +3 more
openalex +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Path Tracking Controller Design of Automated Parking Systems via NMPC with an Instructible Solution
Parking difficulties have become a social issue that people have to solve. Automated parking system is practicable for quick par operations without a driver which can also greatly reduces the probability of parking accidents.
Liang Chen +4 more
doaj +1 more source
Historical perspectives on thermostructural research at the NACA Langley Aeronautical Laboratory from 1948 to 1958 [PDF]
Research on structural problems associated with aerodynamic heating, conducted by the National Advisory Committee for Aeronautics (NACA) during its last decade are described. The text of a special presentation given at the NASA Symposium on Computational
Heldenfels, R. R.
core +1 more source
Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source

