Results 61 to 70 of about 282,137 (268)
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Chengshi guidao jiaotong yanjiuObjectiveTo analyze the welding materials and welding parameters used in the actual frame repair welding process, it is necessary to investigate the influence of different process parameters on the welding mechanical properties of the high-strength low ...
Cheng LI +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
The latest technical solutions in rail vehicles drives
MATEC Web of Conferences, 2017 The article discusses the latest trends and solutions used in the offers of rail vehicles manufacturers. The study is mainly concerned with the technical solutions used in hybrid rail vehicles, whose development has become one of the priorities for the ...
Andrzejewski Maciej +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty +13 more
wiley +1 more source
Experimental Study on Fault Simulation of Axle-end Grounding Devices for High-speed Train
Chengshi guidao jiaotong yanjiuObjectiveAffected by current-carrying friction operating characteristics, axle-end grounding devices of high-speed trains are prone to failure. To support effective vehicle inspection, maintenance, and fault diagnosis, it is necessary to investigate the ...
Guannan LIU +4 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Chengshi guidao jiaotong yanjiu［Objective］ Due to the relatively confined space and high passenger capacity of metro trains, fire safety and life protection are attracting significant attentions in the public transportation industry. To evaluate the emergency evacuation model of metro
LIU Yantong +3 more
doaj +1 more source
Water Transport - The Challenge for the Automotive Industry in Slovakia
Communications, 2016 An important factor in choosing the transport mode in the automotive industry is not only the current price but also the shipping time. In some cases the latter one is even crucial and significantly affects the choice of the transport mode.
Tomas Kalina +3 more
doaj +1 more source
Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source