Results 41 to 50 of about 282,137 (268)

Analysis of Suppression Effect on Air Particulate Matter Propagation Distance in High-speed Train Passenger Compartments Based on Flow Field Optimization

Chengshi guidao jiaotong yanjiu
ObjectiveIn the enclosed environment of high-speed train passenger compartments, air circulation is restricted, and pollutants may accumulate and spread within the limited space, directly affecting passenger comfort and safety.
Zhongguo BI, Kai BI, Jinlong ZHAO, Lizhong WANG, Chao LI, Hongda DENG   +5 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Vibration Reduction and Noise Control Technologies for Abnormal High-speed EMU Vehicle End Vibration

Chengshi guidao jiaotong yanjiu
ObjectiveWhen high-speed EMUs (electric multiple units) operate at speeds exceeding 300 km/h, vehicle end abnormal vibrations may occasionally occur, leading to increased interior noise and resonance phenomena.
Qingbo LIU, Dongwei XIA, Ang LI, Haiying XING, Pengfei DUAN   +4 more
doaj   +1 more source

Model predictive eco-driving control of internal-combustion-engine vehicles equipped with CVTs in car-following scenarios

SICE Journal of Control, Measurement, and System Integration, 2023
Eco-driving control is a key technology for achieving carbon neutrality of vehicles equipped with automated-driving systems and advanced driver-assistance systems.
Shinsaku Yoshinaka, Satoru Narisawa, Tsuyoshi Yuno, Wenjing Cao, Masakazu Mukai, Taketoshi Kawabe   +5 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Technical Study on Prepreg Front-end Fiberglass Head Covers for Urban Rail Transit Vehicles

Chengshi guidao jiaotong yanjiu
ObjectiveAs a critical component of urban rail transit vehicles, the front-end head cover plays a decisive role in the overall vehicle mass balance due to its unique shape and installation position. Therefore, head cover designs that are easy to form and
Kun ZHOU, Bo NIE, Lu WANG, Chunhe DI, Weiyi DUAN   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Underframe Skirt Structure of Suburban Railway Trains

Chengshi guidao jiaotong yanjiu
ObjectiveThe underframe skirt panels of suburban railway trains are arranged on the side of the equipment beneath the vehicle, which can optimize the aerodynamic performance of the underframe area, reduce air resistance, and provide convenience for the ...
Hanqin MIN, Weiguo MA, Dengke GAO, Hongyuan YI   +3 more
doaj   +1 more source