Results 21 to 30 of about 720,508 (305)

Research on Maintenance Modes of City Rail Transit Vehicles

Chengshi guidao jiaotong yanjiu
［Objective］ City rail transit vehicles are specifically designed and developed models to adapt to city rail transit lines, differing in operational environment, line parameters, and vehicle configurations from high-speed railway EMU and urban rail ...
WANG Tiemin, WAN Tiejun, LIU Wenbo, GUO Jianping, XU Wenyao, HOU Jixuan, MA Xuan   +6 more
doaj   +1 more source

“I Ought to Be Getting Him His Feed”: Masculinity Regained in Edith Wharton’s Ethan Frome

Gender Studies, 2023
This paper discusses the masculinity of the protagonist Ethan in Edith Wharton’s Ethan Frome in relation to the vehicles he uses. Ethan, who attempts to commit suicide by sledding down a hill with his wife’s cousin Mattie so as to flee his unhappy ...
Yoshino Narumi
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Performance Analysis and Application Prospects of New Silicon-Carbon Anode Materials in Rail Transit Vehicle Soft-pack Batteries

Chengshi guidao jiaotong yanjiu
［Objective］ The large-scale application of silicon-containing anode materials in soft-pack battery for urban rail transit vehicles faces many challenges, primarily the failure of electrical performance due to the volume expansion of silicon.
SHI Lei, GAO Yang, WANG Jian, XIANG Weiran, JIN Shengjie, HAN Duo, WANG Siqi   +6 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Mechanical Performance Analysis of Design Scheme for High-speed Train Obstacle Deflector with Built-in Aluminum Honeycomb Covered Energy Absorber

Chengshi guidao jiaotong yanjiu
［Objective］ The OD (obstacle deflector) serves as a primary passive safety device on high-speed trains, effectively clearing obstacles between the wheels and the tracks.
LI Hongshuang, LI He, XU Peng, ZHANG Haomiao, QIU Zhengcheng   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Wheel Load Calculation Methods for Articulated Suburban Railway Trains

Chengshi guidao jiaotong yanjiu
Objective The distribution of wheel loads and axle loads plays a critical role in train operational safety and structural reliability, and the accuracy of wheel load calculation is an important prerequisite for the vehicle's top-level design.
Feng QIANG, Jun JIANG, Xuefei LI, Xiping NIU, Wenhua WANG, Hongtao LIU   +5 more
doaj   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Design and Analysis of Traction-Bolster Buffer Structure for Rail Transit Vehicle Aluminum Alloy Carbodies Based on Axlebox-integrated Bogies

Chengshi guidao jiaotong yanjiu
ObjectiveAIBs (axlebox-integrated bogies) feature high equipment space utilization and superior performance. To match such bogies and meet the lightweight development requirements of urban rail transit vehicles, it is necessary to design a novel traction-
Zhanyu XIE, Zhuoda XIE, Yanxiang WANG, Pengfei LI, He SHI, Hongyuan YI   +5 more
doaj   +1 more source