Results 31 to 40 of about 282,137 (268)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Fault Diagnosis and Prognostic Model Based on Bearing Data of Urban Rail Transit Vehicles
Chengshi guidao jiaotong yanjiuObjectiveFor predictive maintenance of bearings in urban rail transit vehicles, existing fault diagnosis models exhibit limitations. On the one hand, constrained by specific operating conditions and single data distribution, the models’ performance ...
Lianfu WANG +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Cause Analysis and Solution for Vertical Damper Mounting Bolt Loosening in High-Speed Railway EMU
Chengshi guidao jiaotong yanjiu［Objective］ During the operation of a certain type of high-speed EMU (electric multiple units) in China, the mounting bolts at lower rubber joint of the secondary vertical damper (hereinafter referred to as the ′lower joint′) experience loosening.
HAN Guangxu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Design Method of Carbody Front-end Energy-absorption Device for High-speed Trains
Chengshi guidao jiaotong yanjiuObjectiveTo optimize the passive safety protection performance of high-speed trains, it is necessary to design a carbody front-end energy-absorption device suitable for high-speed trains, so as to reduce the carbody deformation during collisions and ...
Shihong JIANG +4 more
doaj +1 more source
Structural Design of Obstacle Deflector on Type-A City Rail Transit Train
Chengshi guidao jiaotong yanjiu［Objective］ European standard EN 15227:2020 stipulates that except the obstacle-clearing capabilities, OD (obstacle deflector) should also have energy absorption functions, specifying the energy absorption values required for trains at different speed ...
DUAN Pengfei +3 more
doaj +1 more source
Agricultura Tropica et Subtropica, 2022 This study examined how the nature of rural transportation networks affects the income of local farmers. The study involved arable crop farmers in the Ilaje local government area of Ondo State, Nigeria.
Olagunju Oluwatoyin
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source