Results 81 to 90 of about 24,577,898 (230)

Molecular Dynamics‐Guided Sterol Engineering of mRNA‐Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen‐Selective Immunity

Advanced Science, EarlyView.
Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon, Seo‐Hyeon Bae, Jungyong Ji, Jisun Lee, Hosam Choi, Min‐Ho Kang, Sang‐In Park, Hyemin Kim, Nakyung Lee, Hajin Lee, Seonghoon Kim, Jungmin Kim, Subin Yoon, Seonghyun Lee, Seongje Cho, Dahyeon Ha, Ayoung Oh, Sohee Jo, Huijeong Choi, Yeeun Lee, Sowon Lee, Hyo‐Jung Park, Gitak Nam, Jisu Shin, Yujin Kang, Wonpil Im, Kiyoun Lee, Jae‐Hwan Nam   +27 more
wiley   +1 more source

Graph Based Cooperative Forwarding in Information Centric Vehicular Networks

IEEE Access
The rise of data intensive applications reveal the limitations of IP-based networking, particularly in dynamic vehicular environment. Transitioning to Information Centric Network (ICN) addresses these limitations by focusing on content retrieval from any
Beri Surya Samantha, Nitul Dutta, Rajesh Mahadeva, Shashikant P. Patole, Gheorghita Ghinea   +4 more
doaj   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

Named data networking in vehicular environment: forwarding and mobility

, 2018
Electronic Thesis or DissertationVehicular networking has become an attractive scenario, where Intelligent Transportation Systems can provide tremendous benefits.
Kuai, Meng
core   +1 more source

A Visual-Information-Based Forwarding Mechanism Incorporating Travel-Route-Aware Design in NDN-Based VANETs

IEEE Access
Named Data Networking (NDN) has emerged as a promising solution to address high mobility and intermittent connectivity in vehicular ad hoc networks (VANETs).
Minh Ngo, Satoshi Ohzahata, Ryo Yamamoto
doaj   +1 more source

Real-Time Vehicle Tracking-Based Data Forwarding Using RLS in Vehicular Named Data Networking

Vehicular Named Data Networking (VNDN) is a new architectural paradigm that combines Named Data Networking (NDN) with Vehicular Ad Hoc Networks (VANETs). VNDN enables vehicles to request and receive named content in vehicle network environment.
Khan, Sajjad Ahmad, Lim, Huhnkuk
core   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

Poster: Smart networked bicycles with platoon cooperation [PDF]

, 2015
Urban roads are venues of social interaction where many actors try to accomplish their transportation-related individual goals. It has been demonstrated that when individuals act with scarce contextual information they offer resistance to one another's ...
Sacanamboy, Juan Camilo, Cespedes Umaña, Sandra Lorena, Salamanca Constain, Hugo, Vehicular Networking Conference, VNC   +3 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Molecular Bases and Genetic Design of Rice Disease Resistance for Optimized Yield and Sustainable Agriculture

Advanced Science, EarlyView.
This study integrates rice immune perception, signal transduction, and resistance output into a multi‐omics framework. By combining high‐throughput sequencing, phenomics, and AI‐assisted design with marker‐assisted selection, gene editing, and rapid domestication, we aim to accelerate the precise breeding of disease‐resistant rice varieties by ...
Xinyue Hou, Yuanjiang Cui, Chaoqing Ding, Qian Qian, Deyong Ren   +4 more
wiley   +1 more source