Results 151 to 160 of about 1,056,846 (316)

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

open access: yesAdvanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz   +9 more
wiley   +1 more source

Treatment Options For Retinal Vein Occlusion

open access: yes, 2023
In this literature review I address the basic concepts involved in the development of retinal vein occlusion, the risk factors, clinical course of the disease, diagnostic procedures, and the available management options.
Ajene, Comfort-Lucia
core  

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

open access: yesAdvanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett   +7 more
wiley   +1 more source

Tumor‐Targeted Hyaluronic Acid/Tannic Acid‐Engineered Oxygen Nanogenerators With IR780 Payloads Enable Dual‐Mode Glutathione Depletion and Effective Singlet Oxygen Generation for Melanoma Treatment

open access: yesAdvanced Healthcare Materials, EarlyView.
A hyaluronic acid/tannic acid‐engineered Prussian blue oxygen nanogenerator loaded with IR780 is developed to enhance melanoma phototherapy. By integrating tumor targeting, oxygen self‐supply, and dual‐mode glutathione depletion, the nanoplatform effectively overcomes hypoxia and antioxidant defenses, potentiating synergistic photothermal/photodynamic ...
Chai‐How Hsu   +7 more
wiley   +1 more source

Overcoming Photodynamic Therapy Resistance: GSH‐Responsive AIE Photosensitizer‐Hydroxycamptothecin Nanoliposomes for Extrahepatic Cholangiocarcinoma

open access: yesAdvanced Healthcare Materials, EarlyView.
A GSH‐responsive AIE nanoplatform (TSH NPs) with RGD‐mediated tumor targeting co‐delivers a photosensitizer (TPA) and HCPT for extrahepatic cholangiocarcinoma. The system synergistically enhances PDT and chemotherapy by suppressing HIF‐1α/VEGF‐driven hypoxic adaptation, effectively overcoming PDT resistance.
Yong Qu   +19 more
wiley   +1 more source

Spatially Controlled Embedded Bioprinting of Prevascularized Spheroids‐Containing Biopatch Enables Functional Skin Regeneration

open access: yesAdvanced Healthcare Materials, EarlyView.
A spatially controlled embedded bioprinting strategy enables precise engineering of prevascularized multicellular spheroids within skin‐derived dECM bioinks. Optimized spheroid size, composition, and spacing promote vascular maturation, paracrine signaling, and tissue integration, resulting in enhanced angiogenesis, blood perfusion, and functional skin
Minjun Ahn   +6 more
wiley   +1 more source

Antiphospholipid syndrome: ophthalmologic manifestations. A review

open access: yesТерапевтический архив
Antiphospholipid syndrome presents with a variety of symptoms, including eye damage. Vision pathologies associated with this syndrome affect both the anterior and posterior segments of the eye, causing a variety of changes.
Farida R. Sayfullina   +2 more
doaj   +1 more source

Multiwavelength Implantable Oximeter for Wireless Monitoring of Tissue Oxygenation in the Presence of Blood Volume Changes

open access: yesAdvanced Healthcare Materials, EarlyView.
This study presents an implantable, wireless, battery‐free oximeter that can continuously monitor physiologically consistent regional tissue oxygenation under dynamic changes of blood volume. This is achieved through multiwavelength photoplethysmography and validated both via Monte Carlo simulations and in vivo rat studies. Different stress events were
Anat Usatinsky   +12 more
wiley   +1 more source

Silicone Breast Implants as a Model System for Understanding Polymer Permeation in Soft Materials In Vivo

open access: yesAdvanced Healthcare Materials, EarlyView.
Silicone breast implants are presented as a model system for understanding polymer permeation in vivo. Rather than representing material failure, “gel bleed” emerges from solution–diffusion transport‐mediated. By integrating polymer architecture, physicochemical transport, and biointerfacial processes, this review provides a unified framework that ...
D. Bouyer   +12 more
wiley   +1 more source

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