A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang +2 more
wiley +1 more source
Dynamic Modulation of the Microenvironment Promotes Functional Maturation of Engineered Tissues
Engineered tissues lack the dynamic microenvironment of native tissues. A biocompatible, diffusible small molecule to dynamically modulate tissue microenvironments during maturation is used. Timing‐dependent modulation yields distinct outcomes, producing thicker, more native‐like blood vessels, stronger and more mature cardiac tissues, and optimized ...
Eric Silberman +7 more
wiley +1 more source
Portal vein recanalization without TIPS via a submillimeter cavernomatous channel in non-cirrhotic extrahepatic portal vein obstruction. [PDF]
Yamamoto M +3 more
europepmc +1 more source
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim +4 more
wiley +1 more source
Four and a half Lin11, Isl-1, Mec-3(LIM) domain protein 1 (FHL1) regulates vascular remodeling in low-flow vein grafts. [PDF]
Wang C +8 more
europepmc +1 more source
Three‐Dimensional Ovary Model to Improve and Study Murine Follicle Growth
To develop new methods for fertility preservation in women, novel culture systems for small follicles need to be established. In this work, a poly(ethylene glycol) based scaffold, with appropriate mechanical and bioactive features to support mouse follicle and ovary cell growth is developed, and the formed cell‐follicle interactions are visualized ...
Mira Jacobs +6 more
wiley +1 more source
A Case of Robot-Assisted Ileocecal Resection for Ascending Colon Cancer with Ileocolic Vein Flowing into the Jejunal Vein: Case Report. [PDF]
Kobayashi K +16 more
europepmc +1 more source
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang +12 more
wiley +1 more source
Microscopic ligation combined with shunt procedure versus microsurgical varicocelectomy for nutcracker syndrome and left varicocele: a randomized controlled trial. [PDF]
Dou K +6 more
europepmc +1 more source

