Results 61 to 70 of about 3,676,532 (276)

Intra-Set Velocity Decline and Set-to-Set Changes During a Standardized Moderate-Load Back Squat Protocol in Trained Track and Field Athletes

Applied Sciences
Velocity-based training (VBT) is widely used to monitor resistance training intensity and fatigue through movement velocity. However, repetition-by-repetition velocity behavior and set-to-set fatigue responses under standardized moderate-load conditions ...
Bumchul Chung
doaj   +1 more source

The influence of interstitial cells of Cajal loss and aging on slow wave conduction velocity in the human stomach

Physiological Reports, 2021
Loss of interstitial cells of Cajal (ICC) has been associated with gastric dysfunction and is also observed during normal aging at ~13% reduction per decade. The impact of ICC loss on gastric slow wave conduction velocity is currently undefined.
Tim Hsu‐Han Wang, Timothy R. Angeli, Shunichi Ishida, Peng Du, Armen Gharibans, Niranchan Paskaranandavadivel, Yohsuke Imai, Taimei Miyagawa, Thomas L. Abell, Gianrico Farrugia, Leo K. Cheng, Gregory O’Grady   +11 more
doaj   +1 more source

Effect of the Radial Velocity Distribution on the Loss Generation of a Contra-Rotating Fan in a Ventilation System

Entropy, 2023
Quantification of the loss generation of ducted contra-rotating fan (CRF) blades is difficult to achieve, since there are no guide vanes between rotors.
Xingyu Jia, Xi Zhang, Kui Guo, Xuehui Li
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The effect of velocity-based strength training on lower limb maximal strength, power, and muscle thickness: a comparative study of sex-specific adaptations

Frontiers in Physiology
PurposeThis study aims to explore the effects of Velocity-Based Strength Training (VBT) on lower-limb strength, power, and muscle thickness in athletes of different sexes.
Longkang Guo, Lintao Suo, Wendong Xue, Jingyuan Yang, Xuehaiyue Lv, Haonan Qi, Mushuai Hao, Liang Zhao, Xiaofu Yang, Wei Han   +9 more
doaj   +1 more source

Small tympanic membrane perforations in the inferior quadrants do not impact the manubrium vibration in guinea pigs. [PDF]

PLoS ONE, 2012
BACKGROUND: It has been believed that location of the perforation has a significant impact on hearing loss. However, recent studies have demonstrated that the perforation sites had no impact on hearing loss.
Xiuling Zhang, Yanhong Dai, Shuyi Zhang, Wandong She, Xiaoping Du, Xiuji Shui   +5 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Post-Activation Potentiation Enhancement of Countermovement Jump Performance using Velocity-based Conditioning Protocols with High-loads in Active Men and Women

Motricidade
Post-activation performance enhancement (PAPE) refers to the temporary improvement in physical abilities resulting from a previous conditioning activity (CA), and velocity-based resistance training has been proposed to optimise PAPE.
Rafael Peixoto, Rui Canário-Lemos, Tiago Moreira, Guilherme Vilela, Gabriela Lucas Chaves, Felipe José Aidar, Filipe Casanova, Gabriela Monteiro, Victor Reis, José Vilaça-Alves   +9 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source