Results 71 to 80 of about 1,108,741 (301)

A Radar-Based Concept for Simultaneous High-Resolution Imaging and Pixel-Wise Velocity Analysis for Tracking Human Motion

IEEE Journal of Microwaves
The radar-based analysis of human motion is actively being researched due to its contact- and markerless nature and ability to measure motion directly via the Doppler effect.
Johanna Braunig, Simon Heinrich, Birte Coppers, Christoph Kammel, Vanessa Wirth, Marc Stamminger, Sigrid Leyendecker, Anna-Maria Liphardt, Ingrid Ullmann, Martin Vossiek   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Doppler Lidar Based on Mode-Locked Semiconductor Lasers

Micromachines
This paper presents a Doppler lidar system based on a mode-locked semiconductor laser (ML-SL) source. The ML-SL consists of two sections: a Fabry–Pérot (F-P) cavity and a saturable absorber (SA) region. The system utilizes multiple phase-correlated modes
Yibing Chen, Mengxi Zhou, Wenxuan Ma, Zhenxing Sun, Yuechun Shi, Hui Zou, Yunshan Zhang   +6 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Direct measurement of quantum phase gradients in superfluid 4He flow

, 2007
We report a new kind of experiment in which we generate a known superfluid velocity in a straight tube and directly determine the phase difference across the tube's ends using a superfluid matter wave interferometer. By so doing, we quantitatively verify
Aditya Joshi, C. F. Barenghi, D. R. Tilley, F. London, J. Clarke, J. S. Langer, L. D. Landau, R. J. Donnelly, R. J. Donnelly, R. P. Feynman, Richard Packard, Yuki Sato   +11 more
core   +1 more source

Estimation of the Tilt of the Stellar Velocity Ellipsoid from RAVE and Implications for Mass Models [PDF]

, 2008
We present a measure of the inclination of the velocity ellipsoid at 1 kpc below the Galactic plane using a sample of red clump giants from the RAVE DR2 release. We find that the velocity ellipsoid is tilted towards the Galactic plane with an inclination
A. Helmi, A. Siebert, A. Siviero, Alves, Amendt, B. K. Gibson, Battaglia, Belokurov, Bienaymé, Bienaymé, Binney, Binney, Binney, Caldwell, Carlberg, Chereul, Cignoni, Crézé, De Simone, Dehnen, Dehnen, Dehnen, E. K. Grebel, Famaey, Famaey, Fellhauer, G. Gilmore, G. Seabroke, Grillmair, Grillmair, Helmi, Holmberg, Hori, Ibata, J. Binney, J. Bland-Hawthorn, J. F. Navarro, Johnston, Juric, K. C. Freeman, Kuijken, Kuijken, Kuijken, Kuijken, Law, Lynden-Bell, M. Steinmetz, M. Williams, Majewski, Majewski, Martinez-Delgado, Minchev, Newberg, Newberg, O. Bienaymé, Odenkirchen, Ojha, Olling, Ollongren, Oort, Q. A. Parker, R. Campbell, R. F. G. Wyse, Read, Ruzicka, Schlegel, Seabroke, Seabroke, Siebert, Statler, Steinmetz, T. Zwitter, U. Munari, Veltz, Zhao, Zwitter   +75 more
core   +3 more sources

FIELD MEASUREMENTS OF NEARSHORE VELOCITIES

Coastal Engineering Proceedings, 1974
Two component electromagnetic flowmeters are being used as the basis of an apparatus to measure nearshore velocities on natural beaches. The flowmeters are mounted on free standing tripods, 1 m. base side and 0.3 m. high, to measure the two components of horizontal flow, and have been used in depths of up to 4 m. and up to 150 m.
David A. Huntley, Anthony J. Bowen
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

In situ measurement of the electron drift velocity for upcoming directional Dark Matter detectors

, 2014
Three-dimensional track reconstruction is a key issue for directional Dark Matter detection and it requires a precise knowledge of the electron drift velocity. Magboltz simulations are known to give a good evaluation of this parameter. However, large TPC
Billard, J., Bosson, G., Bourrion, O., Guillaudin, O., Iguaz, F. J., Lamblin, J., Lebreton, L., Maire, D., Mayet, F., Richer, J. P., Riffard, Q., Santos, D.   +11 more
core   +3 more sources