Results 61 to 70 of about 3,461,090 (232)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Droplet Velocity in an Electrowetting on Dielectric Digital Microfluidic Device
Micromachines, 2016 In many electrowetting on dielectric (EWOD) based microfluidics devices, droplet actuation speed is a crucial performance-controlling parameter. Our present study aims to characterize and study droplet speed in a typical EWOD device.
Mun Mun Nahar +3 more
doaj +1 more source
Filtering enhanced tomographic PIV reconstruction based on deep neural networks
IET Cyber-systems and Robotics, 2020 Tomographic particle image velocimetry (Tomo-PIV) has been successfully applied in measuring three-dimensional (3D) flow field in recent years. Such technology highly relies on the reconstruction technique which provides the spatial particle distribution
Jiaming Liang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
IEEE Access, 2020 This paper proposed a robust finite-time tracking controller with adaptive neural networks for uncertain robotic manipulators without velocity measurements.
Tie Zhang, Aimin Zhang
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
A Novel Approach for Warhead Fragments Velocity Measurement Based on Laser Screen
Journal of Measurement Science and Instrumentation, 2011 The velocity of warhead fragment is key criteria to determine its mutilation efficiency.We have designed an optoelectronic system to accurately measure the average velocity of warhead fragments.The apparatus including two parallel laser screens spaced ...
Ji LIU, Dong-e ZHAO, Han-chang ZHOU
doaj
Sensors, 2018 Industrial pipelines must be inspected to detect typical failures, such as obstructions and deformations, during their lifetime. In the petroleum industry, the most used non-destructive technique to inspect buried pipelines is pigging.
Renan Pires de Araújo +5 more
doaj +1 more source