Results 51 to 60 of about 44,168 (180)

Nanopore direct RNA sequencing and the epitranscriptome: Advances in mapping native RNA landscapes

iMeta, EarlyView.
Nanopore direct RNA sequencing advances transcriptomics by capturing full‐length transcripts and multiple RNA modifications; this review details its principles, workflows, tools, applications, challenges, and future research potential. Abstract Nanopore direct RNA sequencing (DRS) has transformed transcriptomics by enabling single‐molecule, long‐read ...
Tianyuan Zhang, Jia Li, Chao Tang, You Wu, Hao Wu, Xi‐Tong Zhu, Ziyang Luo, Hang Qin, Lishan Ding, Yu Zeng, Shiou Yih Lee, Xiaotao Shen, Shiwen Gao, Zhaoyang Tian, Qian Tang, Mian Li, Muhammad Tahir Ul Qamar, Yang Dong, Komivi Dossa, Yaxuan Zhang, Hu Chen, Sanqi An, Xiang Yu, Lu Chen, Dingjie Wang, Shengli Li, Ling‐Ling Chen, Yanqiang Li   +27 more
wiley   +1 more source

Reduced venetoclax exposure to 7 days vs standard exposure with hypomethylating agents in newly diagnosed AML patients

Blood Cancer Journal
Hypomethylating agent (HMA) plus venetoclax (VEN) regimens are standard of care in patients with acute myeloid leukemia (AML) ineligible for intensive chemotherapy.
Christophe Willekens, Alexandre Bazinet, Samy Chraibi, Alex Bataller, Justine Decroocq, Naszrin Arani, Benjamin Carpentier, Caitlin Rausch, Delphine Lebon, Abhishek Maiti, Nicolas Gauthier, Nicholas Short, Sarah Bonnet, Koji Sasaki, Sabine Khalife-Hachem, Mahesh Swaminathan, Jean-Baptiste Micol, Florence Pasquier, Christophe Marzac, Damien Roos-Weil, Laurent Pascal, Naval Daver, Tapan Kadia, Didier Bouscary, Farhad Ravandi, Arnaud Pages, Hagop Kantarjian, Stéphane De Botton, Courtney DiNardo   +28 more
doaj   +1 more source

The Renal Function of the Wild Rodent Cerradomys goytaca Reveals Adaptations in the Mechanisms of Urinary Concentration and Solute Excretion

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Renal adaptations of Cerradomys goytaca associated with survival in its natural habitat. Graphical Abstract of the main renal physiological characteristics identified in C. goytaca. This species exhibits an increased kidney mass index, elevated urine osmolality, and enhanced tubular water reabsorption, indicating a higher capacity for water ...
Luzia Agusta Valeriano‐Monici, Carolina de Augusta Barros Silva, Gustavo de Castro Nascimento, Lana Soares Sales, Carlos de Alberto Souza Filho, Edgar Mendes Souza Wan Der Maas Rosa, Patrick Gabriel Alencar dos Santos, Eulogio de Carlos Queiroz Carvalho, Jones Bernardes Graceli, Pablo Rodrigues Gonçalves, Jackson de de Souza‐Menezes   +10 more
wiley   +1 more source

When Does Top Management Team Diversity Matter in Large Organizations?

Journal of Organizational Behavior, EarlyView.
ABSTRACT Top management teams (TMTs) drive strategic leadership, but there is little clarity on when the composition of these upper echelons most impacts organization performance. Drawing from the categorization‐elaboration model, we study an 18‐year sample of approximately 4500 organizations and over 32 000 executives and find a positive relationship ...
Frances Fabian, James M. Plečnik, Shan Wang   +2 more
wiley   +1 more source

Outcomes for Patients With Myeloid Neoplasms Treated With Chemotherapy Plus Venetoclax After Prior Venetoclax Therapy

eJHaem
Background Outcomes for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that have progression after treatment with hypomethylating agent (HMA) and venetoclax (VEN) are poor.
Rafael Madero‐Marroquin, Joseph Cannova, Emily Dworkin, Austin Wesevich, Gregory W. Roloff, Caner Saygin, Mariam T. Nawas, Adam S. DuVall, Satyajit Kosuri, Michael J. Thirman, Olatoyosi Odenike, Wendy Stock, Richard A. Larson, Michael W. Drazer, Anand A. Patel   +14 more
doaj   +1 more source

Human Capital Robotic Integration and Value Creation for Organizations

Journal of Organizational Behavior, EarlyView.
ABSTRACT Due to rapid advancements in artificial intelligence and machine learning, the research conversation has drifted from viewing robots as replacements for humans (i.e., the substitute view) to a view that considers the possible benefits of human–robot collaboration in the workplace (i.e., the complementary view).
Chou‐Yu Tsai, Jason D. Marshall, Rory Eckardt, Shelley D. Dionne, Malte F. Jung, YoYo Tsung‐Yu Hou, Biying Yang   +6 more
wiley   +1 more source

Last‐minute coordination: Adapting to demand to support last‐mile operations

Journal of Operations Management, Volume 71, Issue 2, Page 176-194, March 2025.
Abstract In the highly competitive e‐commerce industry, customer‐facing warehouses are crucial as the “order penetration points” for e‐commerce last‐mile operations. This research examines how warehouses use last‐minute coordination, an unstructured mechanism, to ensure sufficient inventory at the order penetration points. Previous research has focused
Kedong Chen, Hung‐Chung Su, Kevin Linderman, William Li   +3 more
wiley   +1 more source

Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation

Cell Death and Disease
Deregulated apoptosis signaling is characteristic for many cancers and contributes to leukemogenesis and treatment failure in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Apoptosis is controlled by different pro- and anti-apoptotic molecules.
Stefanie Enzenmüller, Alexandra Niedermayer, Felix Seyfried, Vera Muench, Daniel Tews, Ulrich Rupp, Eugen Tausch, Alexander Groß, Pamela Fischer-Posovszky, Paul Walther, Stephan Stilgenbauer, Hans A. Kestler, Klaus-Michael Debatin, Lüder Hinrich Meyer   +13 more
doaj   +1 more source

Exposure-response analyses of venetoclax combined with hypomethylating agents in myelodysplastic syndromes: a retrospective study

Frontiers in Pharmacology
BackgroundVenetoclax (VEN), an orally bioavailable B-cell lymphoma-2 inhibitor, shows promising activity in patients with myelodysplastic syndromes (MDS) when combined with hypomethylating agents (HMAs).
Ji-Xin Tian, Ping Zhang, Xiao-Xu Wang, Jin-Wen Li, Dong-Xue Liu, Yi-Ying Liu, Zhi-Jian Xiao, Wen-Juan Miao   +7 more
doaj   +1 more source

Corporate Psychopaths as Risk Factors: The Role of Managerial Control and Competition for Risk Governance

Strategic Change, EarlyView.
ABSTRACT The increasing prevalence of corporate scandals and dysfunction linked to psychopathic leaders has prompted significant research into the drivers and effects of psychopathy in business. This paper examines corporate psychopathy, focusing on individuals with extreme selfishness, callousness, and manipulative behavior who often achieve ...
Florian Fuchs
wiley   +1 more source