Results 71 to 80 of about 44,168 (180)

Examining Parent, Teacher, School Mental Health Professional, and Researcher Perceptions of a Tier 2 Internalizing Intervention to Promote Feasibility, Usability, and Effectiveness

Psychology in the Schools, EarlyView.
ABSTRACT The purpose of this study was to inform the continued development and refinement of the Resilience Education Program (REP), a Tier 2 targeted intervention for students in grades 4–8 exhibiting early signs of internalizing problems. Parents (n = 7), teachers (n = 7), school mental health professionals (n = 11), and researchers (n = 6 ...
Stephen Kilgus, Andy Garbacz, Katie Eklund, Jessica Willenbrink, Alexandra Barber, Kortni Dubose, Julia Hilbert, Leah Schwartz‐Dodek   +7 more
wiley   +1 more source

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

The Hidden Costs of Coffee Production in the Eastern African Value Chains

Sustainable Development, EarlyView.
ABSTRACT There is increasing recognition that significant hidden costs associated with agrifood systems are not reflected in market prices. Coffee is among the three most traded agricultural commodities in the world and supports the livelihoods of more than 30 million smallholder households.
Annet Adong, Lukas Kornher, Bezawit Beyene Chichaibelu, Aslihan Arslan   +3 more
wiley   +1 more source

The Path to Neutrality: Evaluating Carbon Offsetting Strategies Among Spanish Corporations

Sustainable Development, EarlyView.
ABSTRACT This study examines how offset project characteristics and financial conditions shape the intensity of corporate carbon offsetting in voluntary carbon markets (VCMs). Focusing on a Southern European context, the analysis draws on a longitudinal panel of 357 Spanish firms observed between 2019 and 2022.
Pedro Gil‐García, Arturo Haro‐de‐Rosario, María del Carmen Valls‐Martínez, Carmen Caba‐Perez   +3 more
wiley   +1 more source

Achieving Sustainable Development Goals Through Social Life Cycle Assessment: A Case Study of Portuguese Forest Wood Supply Chains

Sustainable Development, EarlyView.
ABSTRACT Social considerations are often overlooked in efforts to achieve sustainable development, despite being critical for building equitable and resilient global value chains. This study addresses this gap by applying a social life cycle assessment to three key Portuguese forest wood supply chains—uncoated woodfree paper, natural cork stoppers, and
Andreia Santos, Madalena Veloso, Ana Barbosa‐Póvoa, Ana Carvalho   +3 more
wiley   +1 more source

Peace and Inclusive Governance in Sustainable Development: Strengthening Institutions and Environmental Services

Sustainable Development, EarlyView.
ABSTRACT Sustainable Development Goal 16 (SDG 16) emphasizes peace, justice, and strong institutions as essential foundations for sustainable development. This study adopts a desktop‐based qualitative research approach to examine how institutional quality and governance systems influence progress toward SDG 16 and broader development outcomes.
Maryem Souiai, Hind Alkhowar, Haya Al‐Obaidli, Moza Al‐Muhannadi, Noora Alkhelaifi, Maythaa Al‐Kubaisi, Najlaa Al‐Khayareen, Shooq Al‐Sahoti, John N. Hahladakis   +8 more
wiley   +1 more source

Venetoclax-based salvage therapy as a bridge to transplant is feasible and effective in patients with relapsed/refractory AML

Blood Advances
: The B-cell lymphoma 2 inhibitor venetoclax (VEN) in combination with hypomethylating agents has been approved for first-line treatment of patients with acute myeloid leukemia (AML) ineligible for intensive treatment. VEN-containing treatment strategies
Julia M. Unglaub, Richard F. Schlenk, Jan Moritz Middeke, Stefan W. Krause, Sabrina Kraus, Hermann Einsele, Michael Kramer, Sven Zukunft, Joseph Kauer, Simon Renders, Elena Katelari, Christoph Schliemann, Caroline Pabst, Thomas Luft, Peter Dreger, Christoph Röllig, Martin Bornhäuser, Carsten Müller-Tidow, Tim Sauer   +18 more
doaj   +1 more source

Resource reallocation across successive systemic innovations: How Rolls‐Royce shaped the evolution of the turbojet, turboprop, and turbofan

Strategic Management Journal, EarlyView.
Abstract Research Summary Despite the importance of resource reallocation in shaping a variety of strategic outcomes, strategy scholars have paid only limited attention to the processes by which firms reallocate their resources across successive systemic innovations.
Gino Cattani, Mariano Mastrogiorgio, Giuseppe Carignani   +2 more
wiley   +1 more source

Predicting the toxicity-efficacy ratio of venetoclax in real-world patients

Annals of Hematology
This study investigates the pharmacokinetic variability and exposure-response relationships of Venetoclax (VEN) in adult patients with acute myeloid leukemia (AML) who are ineligible for intensive chemotherapy.
Loïc Osanno, Lucy Brocque, Laurent Bourguignon, Carla Delpech, Laure Farnault, Julien Colle, Pauline Roche, Jacques Chiaroni, Caroline Izard, Régis Costello, Mathilde Dacos, Caroline Solas, Chems Djezzar, Joseph Ciccolini, Thomas Cluzeau, Geoffroy Venton, Raphaëlle Fanciullino   +16 more
doaj   +1 more source

Ex vivo characterization of acute myeloid leukemia patients undergoing hypomethylating agents and venetoclax regimen reveals a venetoclax-specific effect on non-suppressive regulatory T cells and bona fide PD-1+TIM3+ exhausted CD8+ T cells

Frontiers in Immunology
Acute myeloid leukemia (AML) is an aggressive heterogeneous disease characterized by several alterations of the immune system prompting disease progression and treatment response.
Giulia Corradi, Giulia Corradi, Dorian Forte, Gianluca Cristiano, Andrea Polimeno, Marilena Ciciarello, Marilena Ciciarello, Marilena Ciciarello, Valentina Salvestrini, Lorenza Bandini, Valentina Robustelli, Emanuela Ottaviani, Michele Cavo, Michele Cavo, Darina Ocadlikova, Antonio Curti   +15 more
doaj   +1 more source