Results 131 to 140 of about 48,358 (256)

Time‐course analysis of cerebral circulation and cardiorespiratory responses to acute central blood volume reduction in healthy young males

Experimental Physiology, EarlyView.
Abstract Central blood volume (CBV) reduction challenges circulatory and respiratory homeostasis, particularly during the initial compensatory phase (0–2 min), when rapid physiological adaptations occur. In this study, we examined dynamic cardiorespiratory responses to CBV reduction using lower‐body negative pressure (LBNP) in 11 healthy young males ...
Marina Feeley, Tomoki Watada, Go Ito, Ai Shimada, Toru Sawai, Hideomi Nakata, Shingo Otsuki, Tadayoshi Miyamoto   +7 more
wiley   +1 more source

Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion

The Journal of Physiology, EarlyView.
Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí, Lucas Arantes Berg, Hector Martinez‐Navarro, Alfonso Bueno‐Orovio, Blanca Rodriguez   +4 more
wiley   +1 more source

An integrated platform for 2‐D and 3‐D optical and electrical mapping of arrhythmias in Langendorff‐perfused rabbit hearts

The Journal of Physiology, EarlyView.
Abstract figure legend Integrated multimodal platform for panoramic cardiac mapping in isolated heart experiments. On the left, an image of the experimental setup during data acquisition showing a Langendorff‐perfused rabbit heart surrounded by three optical cameras (CAM A, B and C) positioned 120° apart, each coupled with high‐power LEDs for panoramic
Jimena Siles, Vinícius Silva, Tainan Neves, Italo Sandoval, Angélica Quadros, Giovanni Weber, Óscar Barquero, Ilija Uzelac, João Salinet   +8 more
wiley   +1 more source

Unveiling sex dimorphism in the healthy cardiac anatomy: Fundamental differences between male and female heart shapes

The Journal of Physiology, EarlyView.
Abstract figure legend We present a shape modelling‐based morphological analysis of sex differences in cardiac anatomy. We conduct our analysis on 456 healthy subjects from the UK Biobank (227M/229F) to uncover sex‐based differences in healthy cardiac morphology.
Beatrice Moscoloni, Cameron Beeche, Julio A. Chirinos, Patrick Segers, Mathias Peirlinck   +4 more
wiley   +1 more source

Compromised cardiopulmonary transition in fetal growth restricted and small for gestational age neonates

The Journal of Physiology, EarlyView.
Abstract figure legend Differences in cardiovascular function between appropriately grown (AG) and fetal growth restricted (FGR) infants after the cardiopulmonary transition at birth. AG infants typically exhibit an increase in left ventricular output (LVO) and stroke volume (SV) in the first few days after birth, along with a reduction in myocardial ...
Zahrah Azman, Arvind Sehgal, Suzanne L. Miller, Kristen J. Bubb, Graeme R. Polglase, Beth J. Allison   +5 more
wiley   +1 more source

Advances in the treatment of hepatocellular carcinoma: An overview of the current and evolving therapeutic landscape for clinicians

CA: A Cancer Journal for Clinicians, EarlyView.
Abstract Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the third leading cause of cancer‐related death worldwide. Contemporary advances in systemic and locoregional therapies have led to changes in peer‐reviewed guidelines regarding systemic therapy as well as the possibility of downstaging disease that may enable some patients
Dimitrios Moris, Alessandro Martinino, Sarah Schiltz, Peter J. Allen, Andrew Barbas, Debra Sudan, Lindsay King, Carl Berg, Charles Kim, Mustafa Bashir, Manisha Palta, Michael A. Morse, Michael E. Lidsky   +12 more
wiley   +1 more source

What's Your Diagnosis? Large Mediastinal Mass in a Dog

Veterinary Clinical Pathology, EarlyView.
Rosane O. Cruz, Talles M. Almeida, Iris D. S. Menezes, Ludmila R. Moroz, Suane N. Boaventura, Tiago Peixoto, Stella F. Valle, Nicole Hlavac   +7 more
wiley   +1 more source

Artificial Intelligence Software Changes Rare Disease Testing Strategy in Real Time: An International Case Series Using Face2Gene

American Journal of Medical Genetics Part A, Volume 197, Issue 11, November 2025.
ABSTRACT Genetic disorders commonly share features such as developmental delays, cognitive impairment, and behavioral challenges, yet many conditions also present unique dysmorphic features that distinguish them. Performing a thorough medical and family history and a detailed physical exam with attention to dysmorphic features is often the first step ...
Natasha L. Rudy, Adriana Gomes, Tinatin Tkemaladze, Omar Abdul‐Rahman, Drew Cratsenberg, Giulia Pascolini, Giovanni Di Zenzo, Daniele Castiglia, Emily Black, Camerun Washington, Lauren Chad, Cynthia Curry, Miguel Del Campo, Nicole Fleischer, Lynne M. Bird, Anna C. E. Hurst   +15 more
wiley   +1 more source

Investigation of the Effect of Isotonic Drinks on Quantitative MRI Markers of the Liver and Spleen

NMR in Biomedicine, Volume 38, Issue 11, November 2025.
Dynamic models relating liver and spleen T1 to three different amounts of isotonic drinks (0.5, 1.0, and 1.5 L) are described, and the dependence of liver T1, stiffness, volume, and fat fraction on isotonic drinks is discussed. Only T1 prolongation bore clinical significance, and the time constants of dynamic models were dependent only on the volume of
Natassa N. Pittas, Michael Pavlides, Ferenc E. Mózes   +2 more
wiley   +1 more source

Association of Anaesthetists guidelines: safe vascular access 2025

Anaesthesia, Volume 80, Issue 11, Page 1381-1396, November 2025.
Summary Introduction Safe vascular access is integral to anaesthetic and critical care practice. However, despite technological and procedural advances, it remains a frequent source of adverse events and patient harm. Ensuring a safe and effective approach to the selection, insertion and care of vascular access devices should be a priority for all ...
Andrew J. Johnston, Matthew J. Simpson, Victoria McCormack, Andrew Barton, James Bennett, Anil Chalisey, Jeremy Crane, Stefanie Curry, Helen Laycock, Dhupal Patel, Teikchoon See, John Shubhaker, Kathryn Singh, Sarah Thornton   +13 more
wiley   +1 more source