Results 31 to 40 of about 4,351 (98)

Treatment of Intermediate‐Risk Hepatoblastoma Using a Combined Cisplatin and Doxorubicin (PLADO) Regimen and Optimized Surgical Resection

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Complete resection of the primary tumor is critical for the survival of children with hepatoblastomas (HBs). This prospective clinical study aimed to clarify the outcome of a chemotherapy regimen comprising cisplatin and doxorubicin (PLADO) followed by definitive surgery conducted at the appropriate time in patients with ...
Tomoro Hishiki, Kohmei Ida, Kenichiro Watanabe, Makiko Mori, Junya Fujimura, Yuki Nogami, Tomoko Iehara, Ken Hoshino, Akiko Yokoi, Shohei Honda, Takuro Kazama, Masahiro Sekiguchi, Norihiko Kitagawa, Risa Matsumura, Motonari Nomura, Yohei Yamada, Ryo Hanaki, Hide Kaneda, Yuichi Takama, Takeshi Inoue, Yukichi Tanaka, Osamu Miyazaki, Hiroki Nagase, Tetsuya Takimoto, Kenichi Yoshimura, Eiso Hiyama   +25 more
wiley   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Coculture of Bifidobacterium bifidum G9‐1 With Butyrate‐Producing Bacteria Promotes Butyrate Production

Microbiology and Immunology, EarlyView.
ABSTRACT Supplementation with Bifidobacterium bifidum G9‐1 (BBG9‐1) has been established to enhance the production of butyrate, a short‐chain fatty acid (SCFA) known for its beneficial effects in alleviating constipation. We hypothesized that BBG9‐1 alters gut microbiota such that bacteria that produce butyric acid from lactate and acetate become more ...
Haruka Yokota, Yoshiki Tanaka, Hiroshi Ohno   +2 more
wiley   +1 more source

Senescent Macrophages Promote Age‐Related Revascularization Impairment by Increasing Antiangiogenic VEGF‐A165B Expression

Aging Cell, EarlyView.
The underlying mechanisms of age‐related revascularization impairment are not clear. Our research firstly identified that macrophages were more senescent in the ischemic skeletal muscle of old mice and senescent macrophages could inhibit revascularization.
Minghong Chen, Junyu Chen, Yu Liu, Xuerui Wang, Meilian Yao, Jing Chen, Jian Zhang, Qun Huang   +7 more
wiley   +1 more source

Measurement and interpretation of central venous pressure: a narrative review

Anaesthesia, EarlyView.
Summary Introduction Central venous pressure has been a key component of haemodynamic monitoring for several decades, but its clinical utility is still debated. While central venous pressure has been used traditionally to assess intravascular volume status and fluid responsiveness, mounting evidence suggests that its absolute value alone is an ...
Patryck Lloyd‐Donald, Midori Fujino, Boris Waldman, Lachlan F. Miles   +3 more
wiley   +1 more source

Partial agenesis of the corpus callosum: Prenatal ultrasound characteristics, associations, and outcome

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Abnormal cavum septi pellucidi is the most common indirect sign of partial agenesis of corpus callosum (pACC). A cystic mass in the midline that communicates with the third ventricle may be an indirect sign of pACC. PACC is highly associated with intra‐ and extracranial malformations.
Changrong Zhou, Hezhou Li, Ruizheng Han, Hongrui Ren, Bin Shen, Xinxia Wang, Fangfang Feng, Mengmeng Wang, Ling Liu   +8 more
wiley   +1 more source

Ultrasound Assessment of Venous and Pulmonary Congestion in Left Ventricular Assist Devices Patients

Artificial Organs, EarlyView.
Renal venous stasis index (RVI) of Doppler renal ultrasound index is the peripheral vein ultrasound associated with high right atrial pressure, and right displacement of the interatrial septum is the echocardiographic parameter associated with high pulmonary wedge pressure.
Attilio Iacovoni, Cinzia Giaccherini, Sara Paris, Raffaele Abete, Claudia Vittori, Riccardo Maria Inciardi, Ottavio Zucchetti, Amedeo Terzi, Michele Senni   +8 more
wiley   +1 more source

Simultaneous Ex Situ Normothermic Perfusion of Paired Kidneys in Pigs

Artificial Organs, EarlyView.
This pig model of simultaneous perfusion of paired kidneys in normothermia suggests that intra‐individual variation is relatively low, enabling one kidney to be employed as a reliable comparator of the other kidney for assessing treatments before kidney transplantation.
Margaux Navez, Nicholas Gilbo, Morgan Vandermeulen, Tiago Pinto Coelho, Pauline Erpicum, Marc Gilbert Lagny, Clarisse Malisoux, Claire Guarin, Gabriel Thierry, Pierre Delanaye, Etienne Cavalier, François Jouret, Olivier Detry   +12 more
wiley   +1 more source

NSun2‐Mediated tsRNAs Alleviate Liver Fibrosis via FAK Dephosphorylation

Cell Proliferation, EarlyView.
NSun2 deficiency inhibited sinusoidal capillarization, alleviating liver fibrosis. Reduced NSun2 expression led to alterations in the functional tsRNAs tRF‐1‐S25 and tRF‐5‐V31, which regulate sinusoidal capillarization by targeting key proteins, including DUSP1 and FAK – crucial clinical targets – offering a novel RNA‐based therapeutic approach for ...
Pengcheng Li, Sunyang Ying, Yu Zou, Xin Wang, Runxue Zhang, Cheng Huang, Moyu Dai, Kai Xu, Guihai Feng, Xin Li, Haiping Jiang, Zhikun Li, Ying Zhang, Wei Li, Qi Zhou   +14 more
wiley   +1 more source

Ultrasound fundamentals and their clinical implications for interventional cytopathologists

Cytopathology, EarlyView.
Interventional cytopathologists need to know about ultrasound physics and instrumentation to produce an image that faithfully recreates the lesion discovered by the sonographer and diagnosed by the radiologist. A deep quantitative understanding of physics is not required.
David Lieu
wiley   +1 more source