Results 31 to 40 of about 64,526 (295)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Paleoflora (Fabaceae and Anacardiaceae) from the Andalhuala formation (lower Pliocene), Catamarca province, Argentina. [PDF]

, 2006
Se describe una flora constituida por impresiones de hojas colectada en la localidad Pie del Médano, (sobre ruta nacional 40, km 914-915) en la provincia de Catamarca. Procede de la Formación Andalhuala que en esa localidad tiene una datación de 5.22 ± 0.
Anzótegui, Luisa Matilde, Herbst, Rafael, Horn, Maricel Yanina   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Fístula arterio venosa traumática de los vasos femorales

Cirugía del Uruguay, 2020
Presentado en sesión de 6 de junio de ...
Walter Suiffet, Jorge Burgel
doaj  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Fístulas arterio venosas congénitas de los miembros

Cirugía del Uruguay, 2020
Presentado en sesión de 11 de noviembre de ...
Walter Suiffet
doaj  

CARACTERIZACION MORFOLOGICA DE COLECTAS DE AGUACATE DEL SUR DEL ESTADO DE MEXICO [PDF]

, 2014
En el Estado de México, geográficamente se encuentra una porción de la franja aguacatera de México. Esta región cuenta con condiciones climáticas heterogéneas representadas en microclimas que ha permitido la generación de una amplia diversidad de ...
Flores Ayala, Felipe, Flores Ayala, Felipe   +1 more
core  

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Aproximación a la lengua de los tratados hipocráticos De fistulis y De haemorrhoidibus [PDF]

, 2003
A partir de una aproximación previa en un trabajo anterior a propósito de aspectos fonéticos y morfológicos en dos tratados quirúrgicos del Corpus Hippocraticum, De fistulis y De haemorrhoidibus, en el presente artículo se quiere continuar esta labor en ...
Labiano, Mikel
core