Results 61 to 70 of about 23,012 (290)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Teeth Wear With Dentin Hypersensitivity Restored By Ceremic Occlusal Veneers
International Dental JournalAim or purpose: In this study, occlusal ceramic veneers were used to restore posterior teeth with severe wear and dentin hypersensitivity. A 3 to 4 years follow-up was conducted to observe the clinical outcomes.
Peng Wang
doaj +1 more source
The Evolution of Dental Materials over the Past Century: Silver and Gold to Tooth Color and Beyond. [PDF]
, 2019 The field of dental materials has undergone more of a revolution than an evolution over the past 100 y. The development of new products, especially in the past half century, has occurred at a staggering pace, and their introduction to the market has been
Bayne, SC +4 more
core +1 more source
A clinical longitudinal study 323 porcelain laminate veneers. Period of study from 3 to 11 years [PDF]
, 2010 Objective: The objective of this study was to evaluate the clinical results of 323 porcelain laminate veneers over a period of 3 to 11 years. Material and Methods: This study included 70 patients, aged between 18 and 74 years. Of the 323 total veneers,
Fons Font, Antonio +5 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Journal of Oral Research and ReviewTooth discoloration that cannot be treated with more conservative procedures such as bleaching or microabrasion, requires restorative treatment to mask the unesthetic appearance. Ceramic veneers provide exceptional resistance to wear and abrasion, retain
Rishu Koul, Deepak Kalia, Kamal Verma
doaj +1 more source
Uranium exploration methodology in cold climates [PDF]
, 1980 The uranium prospecting boom of the past decade had, as a major consequence, the rapid development and proliferation of exploration methods for source materials.
Sims, J.M.
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source