Results 241 to 250 of about 390,432 (297)

A traumatic arteriovenous fistula causing venous insufficiency. [PDF]

J Surg Case Rep
Shelton J, Marasinghe A.
europepmc   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Effects of treatment on extracellular fluid changes in the lower extremities of patients with chronic venous insufficiency using bioelectrical impedance analysis. [PDF]

Medicine (Baltimore)
Kim KY, Cho W, Shin HJ.
europepmc   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

Local and Systemic Endothelial Damage in Patients with CEAP C2 Chronic Venous Insufficiency: Role of Mesoglycan. [PDF]

Int J Mol Sci
Santoliquido A, Carnuccio C, Santoro L, Di Giorgio A, D'Alessandro A, Ponziani FR, Angelini F, Izzo M, Nesci A.   +8 more
europepmc   +1 more source

Chronic venous insufficiency increases postoperative complications after Mohs micrographic surgery for lower extremity nonmelanoma skin cancer: A propensity-matched retrospective cohort study. [PDF]

JAAD Int
Talasila S, Nadir U, Jeha GM, Tolkachjov SN.   +3 more
europepmc   +1 more source

Minimally invasive management of chronic venous insufficiency: A case report on combined radiofrequency ablation and sclerotherapy in an obese patient. [PDF]

Int J Surg Case Rep
La Marca MA, Bruno S, Dinoto E, Federico R, Pecoraro F, Mirabella D.   +5 more
europepmc   +1 more source

Analysis of the Combined Effects of a Novel Combination of Hypersmin, Pumpkin Seed and Amaranthus Extracts in an In Vitro Model of Chronic Venous Insufficiency. [PDF]

Nutrients
Ferrari S, Galla R, Mulè S, Molinari C, Uberti F.   +4 more
europepmc   +1 more source