Results 81 to 90 of about 87,372 (292)

Recent advances in understanding acute respiratory distress syndrome [version 1; referees: 2 approved]

F1000Research, 2018
Acute respiratory distress syndrome (ARDS) is characterized by acute diffuse lung injury, which results in increased pulmonary vascular permeability and loss of aerated lung tissue. This causes bilateral opacity consistent with pulmonary edema, hypoxemia,
Peter Wohlrab, Felix Kraft, Verena Tretter, Roman Ullrich, Klaus Markstaller, Klaus Ulrich Klein   +5 more
doaj   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Fluids in ARDS: more pros than cons

Intensive Care Medicine Experimental, 2020
In acute respiratory distress syndrome (ARDS), increased pulmonary vascular permeability makes the lung vulnerable to edema. The use of conservative as compared to liberal fluid strategies may increase the number of ventilator-free days and survival, as ...
Renata de S. Mendes, Paolo Pelosi, Marcus J. Schultz, Patricia R. M. Rocco, Pedro L. Silva   +4 more
doaj   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

VENOUS THROMBOEMBOLISM IN RELATION TO OVARIAN HYPERSTIMULATION SYNDROME: AN APPROACH TO DETERMINING THE LOW-MOLECULAR-WEIGHT-HEPARIN DOSES AND ACTIVITY

Акушерство, гинекология и репродукция, 2016
Ovarian hyperstimulation syndrome (OHSS) is a relatively common complication of ovarian stimulation. The pathophysiology of OHSS is characterised by increased capillary permeability.
I. E. Zazerskaya, N. A. Osipova, T. V. Vavilova, L. V. Barabanova, K. S. Konradi   +4 more
doaj  

多时相计算机断层扫描血管成像对缺血性卒中的应用研究进展 Application of Multiphase Computed Tomography Angiography in Diagnosis and Evaluation of Ischemic Stroke

Zhongguo cuzhong zazhi, 2019
【摘要】 多时相CTA（multiphase CTA，mCTA）作为一项新型颅内血管影像检查技术，可通过追踪造影剂的空间分布及时间变化动态观察动脉峰值期、静脉峰值期及静脉晚期3个不同时相颅内血管显影情况。其特征性影像——“斑点征”可显示不同时相血管管壁的通透性，评估血栓长度及血栓渗透性，并评估颅内侧支循环状态、病变区血管通透性及静脉溶栓效果。本文就mCTA在侧支循环评估、血管通透性检测及血栓渗透性、血栓长度的识别等方面的研究现状和进展进行综述。 【Abstract】 Multiphase CTA (
赵丹萍，刘俊艳
doaj   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

The physiological aspects of traumatic shock [PDF]

, 1942
Thesis (M.A.)--Boston UniversityThe condition known as shock has been recognized and described by the medical profession for a great many years.
Akers, Robert Preston
core   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Early-Stage Alzheimer Disease Image-guided Therapy Clinical Trial Serendipity: Glymphatic Efflux and Prolonged Meningeal Venous Permeability Enhancement. [PDF]

Radiology, 2021
Klibanov AL.
europepmc   +1 more source