Results 61 to 70 of about 296,629 (234)

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Experiences With Surgical Treatment of Chronic Lower Limb Ulcers at a Tertiary Hospital in Northwestern Tanzania: A Prospective Review of 300 Cases. [PDF]

, 2012
Chronic lower limb ulcers constitute a major public health problem of great important all over the world and contribute significantly to high morbidity and long-term disabilities. There is paucity of information regarding chronic lower limb ulcers in our
Rambau, Peter, Benson R Kidenya, Mabula D Mchembe, Kidenya, Benson R, Peter Rambau, Fidelis Mbunda, Stephen E Mshana, Gilyoma, Japhet M, Chalya, Phillipo L, McHembe, Mabula D, Phillipo L Chalya, Mbunda, Fidelis, Mshana, Stephen E, Japhet M Gilyoma   +13 more
core   +2 more sources

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Inter-rater reliability of the EPUAP pressure ulcer classification system using photographs [PDF]

, 2004
Background. Many classification systems for grading pressure ulcers are discussed in the literature. Correct identification and classification of a pressure ulcer is important for accurate reporting of the magnitude of the problem, and for timely ...
Tom Defloor, Lisette Schoonhoven, Schoonhoven, L., SCHOONHOVEN, L, Defloor, Tom, Schoonhoven, Lisette, Defloor, T.   +6 more
core   +1 more source

A Metal‐Polyphenol Self‐Assembled Coated 3D Sponge With Mild Photothermal Antibacterial, Exudate‐Controlling, and Immunomodulatory Functions for Hemostasis and Chronic Wound Healing

Advanced Science, EarlyView.
A thrombin‐functionalized copper‐polydopamine nanofiber sponge integrates rapid hemostasis, mild photothermal antibacterial therapy, stimulus‐responsive Cu2+ release, chemodynamic oxidative stress, and macrophage immunomodulation. This multifunctional dressing suppresses infection, regulates inflammation, promotes angiogenesis and re‐epithelialization,
Ziwei Zhang, Feng Qin, Xiaomeng Zhang, Xueqin Shuang, Jiahua Zhou, Ming Cheng, Baicheng Lu, Mingyue Song, Yuntian Bai, Dianying Zhang, Ming Li, Yanhua Wang   +11 more
wiley   +1 more source

Management of chronic non-healing venous stasis ulcer through Siddha intervention - a case report

Journal of Ayurveda and Integrative Medicine
Venous stasis ulcer is a chronic vascular disease and majorly occurred in lower limbs. Recurrence of ulcer in lower extremities are common in venous stasis ulcer.
Nikil Niva John Raja, Hema Nandhini Devi Veluchamy, Muthu Vignesh Sivanan   +2 more
doaj   +1 more source

Early versus deferred endovenous ablation of superficial venous reflux in patients with venous ulceration: the EVRA RCT

Health Technology Assessment, 2019
Background: Venous ulceration is a common and costly health-care issue worldwide, with poor healing rates greatly affecting patient quality of life. Compression bandaging has been shown to improve healing rates and reduce recurrence, but does not address
Manjit S Gohel, Francine Heatley, Xinxue Liu, Andrew Bradbury, Richard Bulbulia, Nicky Cullum, David M Epstein, Isaac Nyamekye, Keith R Poskitt, Sophie Renton, Jane Warwick, Alun H Davies   +11 more
doaj   +1 more source

Marjolin's Ulcers at a University Teaching Hospital in Northwestern Tanzania: A Retrospective Review of 56 Cases. [PDF]

, 2012
Marjolin's ulcer is a rare but highly aggressive squamous cell cancer that is most often associated with chronic burn wounds. Although many individual case reports exist, no comprehensive evaluation of Marjolin's ulcer patients has been conducted in our ...
Rambau, Peter, Nestory Masalu, Ssentongo, Robert, Giiti, G., Peter Rambau, Gilyoma, Japhet M, Chandika, A.B, Phillipo L Chalya, Chalya Phillipo L, Joseph B Mabula, Mchembe Mabula D, Giiti Geofrey, Kahima, K.J., Ssentongo, R., Chandika, Alphonce B, Ssentongo Robert, Kahima J Kahima, Mchembe, Mabula D, Geofrey Giiti, Gilyoma Japhet M, Kahima, Kahima J, Mabula D Mchembe, Masalu, N., Giiti, Geofrey, Rambau Peter, Alphonce B Chandika, Rambau, P., Chandika Alphonce B, Masalu Nestory, Chalya, Phillipo L, Masalu, Nestory, Robert Ssentongo, Gilyoma, J.M, Mabula1 Joseph B, Mabula, J.B, Chalya, P.L, Kahima Kahima J, Japhet M Gilyoma, Mabula, Joseph B, Mchembe, M.D   +39 more
core   +1 more source