Results 71 to 80 of about 296,629 (234)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Quality of life assessment of patients with and without venous ulcer

Revista Latino-Americana de Enfermagem, 2014
OBJECTIVES: to compare the quality of life of patients with chronic venous disease with and without ulcer and to identify the most affected aspects.METHOD: cross-sectional study with a sample of 204 patients with chronic venous disease.
Thalyne Yurí Araújo Farias Dias, Isabelle Katherinne Fernandes Costa, Márjorie Dantas Medeiros Melo, Sandra Maria da Solidade Gomes Simões de Oliveira Torres, Eulália Maria Chaves Maia, Gilson de Vasconcelos Torres   +5 more
doaj   +1 more source

Infection with Mansonella perstans Nematodes in Buruli Ulcer Patients, Ghana. [PDF]

, 2014
During August 2010-December 2012, we conducted a study of patients in Ghana who had Buruli ulcer, caused by Mycobacterium ulcerans, and found that 23% were co-infected with Mansonella perstans nematodes; 13% of controls also had M. perstans infection. M.
Abass, KM, Frimpong, M, Richard O. Phillips, Debrah, A, Duah, Mabel Sarpong, Abotsi, J, Debrah, Alexander, Kretschmer, B, Sarfo, FS, Gisela Bretzel, Marc Jacobsen, Sarfo, Fred S., Birte Kretschmer, Ohene Adjei, Bernhard Fleischer, Mark Wansbrough-Jones, Mabel Sarpong Duah, Phillips, Richard O., Jacobsen, M, Justice Abotsi, Abotsi, Justice, Kabiru M. Abass, Bretzel, Gisela, Ampem-Amoako, Y, Adjei, Ohene, Beissner, M, Fleischer, Bernhard, Michael Frimpong, Adjei, O, Alexander Debrah, Abass, Kabiru M., Jacobsen, Marc, Marcus Beissner, Ampem-Amoako, Yaw, Duah, MS, Yaw Ampem-Amoako, Frimpong, Michael, Phillips, RO, Bretzel, G, Wansbrough-Jones, M, Fleischer, B, William Thompson, Thompson, William, Wansbrough-Jones, Mark, Kretschmer, Birte, Thompson, W, Beissner, Marcus, Fred S. Sarfo   +47 more
core   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

VenUS IV (Venous leg Ulcer Study IV) – compression hosiery compared with compression bandaging in the treatment of venous leg ulcers: a randomised controlled trial, mixed-treatment comparison and decision-analytic model

Health Technology Assessment, 2014
Background: Compression is an effective and recommended treatment for venous leg ulcers. Although the four-layer bandage (4LB) is regarded as the gold standard compression system, it is recognised that the amount of compression delivered might be ...
Rebecca L Ashby, Rhian Gabe, Shehzad Ali, Pedro Saramago, Ling-Hsiang Chuang, Una Adderley, J Martin Bland, Nicky A Cullum, Jo C Dumville, Cynthia P Iglesias, Arthur R Kang’ombe, Marta O Soares, Nikki C Stubbs, David J Torgerson   +13 more
doaj   +1 more source

Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease [PDF]

, 2014
Buruli ulcer is a skin disease caused by Mycobacterium ulcerans that is spreading in tropical countries, with major public health and economic implications in West Africa.
Reid Oldenburg (550232), Landier Jordi, Niang, Fatoumata, Sarfo, FS, Sarfo, Fred S, Richard O. Phillips (347896), Mark Wansbrough-Jones, Phillips, Richard O., Forson Mark, Fatoumata Niang (316230), Caroline Demangel (239243), Forson, M, Arnaud Fontanet (157942), Fatoumata Niang, Mark Forson, Niang, F, Oldenburg Reid, Richard O Phillips, Fred S. Sarfo (347891), Jordi Landier (197677), Sarfo Fred S., Fred S Sarfo, Demangel, Caroline, Landier, Jordi, William Thompson, Niang Fatoumata, Demangel, C, Wansbrough-Jones, Mark, Kabiru Abass (550234), Arnaud Fontanet, Wansbrough-Jones Mark, Frimpong, M, Oldenburg, Reid, Richard O. Phillips, William Thompson (241605), Phillips, Richard O, Phillips Richard O., Thompson William, Mark Forson (550235), Sarfo, Fred S., Forson, Mark, Michael Frimpong (550233), Landier, J, Oldenburg, R, Caroline Demangel, Fontanet, A, Frimpong Michael, Abass Kabiru, Fontanet Arnaud, Abass, K, Michael Frimpong, Abass, Kabiru, Frimpong, Michael, Phillips, RO, Wansbrough-Jones, M, Fontanet, Arnaud, Demangel Caroline, Reid Oldenburg, Thompson, William, Mark Wansbrough-Jones (347902), Thompson, W, Kabiru Abass, Jordi Landier, Fred S. Sarfo   +63 more
core   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source

Superficial venous surgery as a management for chronic venous leg ulcers

Al-Azhar Assiut Medical Journal, 2016
Background Venous leg ulcer (VLU) is a chronic problem affecting thousands of patients annually. The aims of this study were to evaluate the effectiveness of saphenous vein surgery as a management for chronic VLUs and to determine which group of ...
Mohamed Mohamed Mogahed, Wessam Mostafa Abdellatif   +1 more
doaj   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source